7691-28-3

Usage

Uses

Used in Chemical Research:
(S)-methyl-2-bromo-3-hydroxypropanoate is used as a reagent for various chemical reactions and synthesis processes. Its unique structure with a bromo and hydroxy group allows for versatile applications in the preparation of complex organic molecules.
Used in Laboratory Settings:
(S)-methyl-2-bromo-3-hydroxypropanoate is used as a reference compound for educational purposes and as a starting material for the synthesis of other organic compounds. Its distinct stereochemistry makes it a valuable tool for teaching and learning about stereoisomers and their properties.
Used in Pharmaceutical Development:
(S)-methyl-2-bromo-3-hydroxypropanoate is used as an intermediate in the synthesis of pharmaceutical compounds. Its structural features can be exploited to create new drugs with potential therapeutic applications.
Used in Material Science:
(S)-methyl-2-bromo-3-hydroxypropanoate is used as a building block for the development of new materials with specific properties, such as polymers with tailored characteristics for various industrial applications.

Upstream product

• 67-56-1 methanol 
• 160732-12-7 acide 2-bromo-3-hydroxy propanoique 
• 292638-85-8 acrylic acid methyl ester 
• 1729-67-5 Methyl 2,3-dibromopropionate 
• 56-45-1 L-serin 
• 186581-53-3 diazomethane 

Downstream Products

• 1428622-74-5 methyl 2-(2-((3-chlorobenzoyl)imino)benzo[d]thiazol-3(2H)-yl)-3-hydroxypropanoate 
• 1428622-72-3 methyl 3-hydroxy-2-(2-((3-(trifluoromethyl)benzoyl)imino)benzo[d]thiazol-3(2H)-yl)propanoate 
• 1428622-70-1 methyl 3-hydroxy-2-(2-((4-methylbenzoyl)imino)benzo[d]thiazol-3(2H)-yl)propanoate 
• 106910-76-3 (RS)-N-benzylserine 

Relevant academic research and scientific papers

CATIONIC CONTRAST AGENTS AND METHODS OF USING THE SAME

Gadolinium complexes for use as contrast agents, and methods for making and using the gadolinium complexes, are described. The contrast agent complexes preferably have a net positive charge, and can electrostatically interact with glycosaminoglycans to improve the delineation of fine tears within cartilage, detection of cartilage degeneration, or assessment of cartilage thickness, morphology, or glycosaminoglycan content via magnetic resonance imaging.

PHENYLIMIDE-CONTAINING BENZOTHIAZOLE DERIVATIVE OF ITS SALT AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

Provided is a phenylimide-containing benzothiazole derivative or its pharmaceutically acceptable salt, a process for the preparation thereof, and a pharmaceutical composition comprising the same. The phenylimide-containing benzothiazole derivative or its pharmaceutically acceptable salt can selectively inhibit the protein-protein interaction between KRS and a laminin receptor (LR), thereby inhibiting migration of cancer cells. Therefore, the phenylimide-containing benzothiazole derivative or its pharmaceutically acceptable salt may be usefully applied for preventing or treating the diseases associated with cancer cell metastasis.

Synthesis of inimers and hyperbranched polymers

An inimer, and process for making same, having the following formula: wherein X=halogen, nitroxide, thioester; R═H or CH3; and R′=aliphatic, non-aliphatic, linear or branched, mesogenic, non mesogenic, chiral, achiral, hydrocarbon, non-hydrocarbon, selected from fluorocarbon, oligo(oxyethylene) and siloxane substituents, alkyl, aryl, mesogenic group, non-mesogenic group, aliphatic, non-aliphatic, siloxane, perfluoroalkyl, perfluoroaryl, or other fluorocarbon group, and polymers, and the process of making them, from the inimer.

PHENYLIMIDE-CONTAINING BENZOTHIAZOLE DERIVATIVE OR ITS SALT AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

The present invention provides a phenylimide-containing benzothiazole derivative or its pharmaceutically acceptable salt, a process for the preparation thereof, and a pharmaceutical composition comprising the same. The phenylimide-containing benzothiazole derivative or its pharmaceutically acceptable salt can selectively inhibit the protein-protein interaction between KRS and a laminin receptor (LR), thereby inhibiting migration of cancer cells. Therefore, the phenylimide-containing benzothiazole derivative or its pharmaceutically acceptable salt may be usefully applied for preventing or treating the diseases associated with cancer cell metastasis.

SYNTHESIS OF INIMERS AND HYPERBRANCHED POLYMERS

An inimer, and process for making same, having the following formula: wherein X=halogen, nitroxide, thioester; R=H or CH3; and R′=aliphatic, non-aliphatic, linear or branched, mesogenic, non mesogenic, chiral, achiral, hydrocarbon, non-hydrocarbon, selected from fluorocarbon, oligo(oxyethylene) and siloxane substituents, alkyl, aryl, mesogenic group, non-mesogenic group, aliphatic, non-aliphatic, siloxane , perfluoroalkyl, perfluoroaryl, or other fluorocarbon group, and polymers, and the process of making them, from the inimer.

Design and regioselective synthesis of (2-Bromo-2-alkoxycarbonyl)ethyl acrylates as inimers for hyperbranched (Co)polyacrylates

A route based on deaminohalogenation of serine is established to synthesize bromoinimers that can be homopolymerized to produce hyperbranched polyacrylates that are true architectural analogues of linear polyacrylates; that is, an ester group is attached to every other carbon along the polymer backbone, and each repeat unit contains a free ester side chain. Georg Thieme Verlag Stuttgart.

A simple and efficient method for regioselective and stereoselective synthesis of vicinal bromohydrins and alkoxybromides from an olefin

(Chemical Equation Presented) A very rapid and efficient method has been developed for the synthesis of vicinal bromohydrins and alkoxybromides directly from an olefin without any catalyst. The reaction was performed in CH 3CN-water (4:1) or alcohol using N,N-dibromo-p-toluenesulfonamide (TsNBr2) as the brominating agent. Excellent yields and regio- and stereoselectivities have been obtained. Bromohydrins are formed instantaneously, whereas formation of alkoxybromides takes 30-60 min.

Structure-Function Relationship of Acyl Amino Acid Surfactants: Surface Activity and Antimicrobial Properties

Amino acid surfactants (AAS), having the general structure α-amino-(N-acyl)-β-alkoxypropionate, were synthesized chemically.Surface activity and antimicrobial properties of the AAS were evaluated.Increases in acyl chain length (i.e., C10-C14) resulted in a linear reduction in surface tension (i.e., 43-36 mN*m-1), as well as dramatic decreases in critical micelle concentrations (cmc) (i.e., 17.9-0.43 mM).Strong correlations existed between the cmc of AAS and their minimal inhibitory concentrations (mic) against Escherichia coli, Pseudomonas aeruginosa, Aspergillus niger, and Saccharomyces cerevisiae.Sensitivity of the microorganisms to the various AAS followed the order Staphylococcus aureus > A. niger= S. cerevisiae> E. coli> P. aeruginosa.In comparison with methyl p-hydroxybenzoate, AAS (MN14) showed 2-8, 64, and 4-8 times the activity against Gram-negative bacteria, Gram-positive bacteria, and fungi, respectively.Surface adsorption and/or bifunctional binding to the cell membrane may account for AAS action on microorganisms.

Kinetics and Mechanism of Bromine Addition to Derivatives of Unsaturated Aliphatic Carboxylic Acids in Aqueous Solution

This paper deals with the kinetics of bromine addition to unsaturated compounds in presence of added bromide ions at 22, 30, 38, 46, and 54 deg C.The substrates used were acrylamide (AAm), methyl acrylate (MA), ethyl acrylate (EA), butyl acrylate (BA), t-butyl acrylate (tBA), methacrylamide (MAAm), methyl methacrylate (MMA), ethyl methacrylate (EMA), methyl crotonate (MC), and ethyl crotonate (EC).The kinetics was followed potentiometrically.The activation parameters (ΔH*, ΔS*, and ΔG*) were calculated and compared.Estimation of product ratio of bromohydrin to dibromide showed the absence of any correlation of the product formation with reactivity of the substrates.The observed parameters are discussed in relation to the proposed reaction mechanisms.

1,3-Dioxolane and 1,3-dioxane polycarboxylates, and precursors thereof

The disclosure relates to: (a) 1,3-dioxolane and 1,3-dioxane polycarboxylates and their precursors having the general formula: STR1 wherein X may be selected from the group consisting of H, CCl3, CO2 R, where R is H or lower alkyl, CO2 M, where M is alkali metal, preferably Na, NH4 or trialkanolammonium, at least three of the X substituents are other than hydrogen, n is 1 or 2, (b) processes for preparing the compounds and precursors of (a) above by the reaction of a halogenated alcohol with a reactive carbonyl to form a halogenated hemi-ketal or hemi-acetal, followed by the reaction with a base to effect cyclization, (c) detergent compositions comprising additions of carboxylate compounds of (a) to enhance detergency as builders, thresholding agents or the like, and (d) water treating processes comprising contacting water containing hardness ions with amounts of carboxylate compounds of (a) effective to sequester, chelate or bind such ions so as to reduce the water hardness and/or improve operations using the thus treated water.