76910-02-6Relevant articles and documents
Synthesis of Polycycles by Single or Double Domino Nucleophilic Substitution/Diels-Alder Reaction
Camps, Pelayo,Lozano, David,Font-Bardia, Mercè
, p. 5013 - 5020 (2015)
New hexacyclo and octacyclo compounds have been synthesized by a short route whose key step consists of a single or double domino nucleophilic substitution of neopentyl-type iodides with potassium cyclopentadienide, followed by intramolecular Diels-Alder cycloaddition.
Synthesis of (±)-1,2,3-triazolo-3′-deoxy-4′-hydroxymethyl carbanucleosides via 'click' cycloaddition
Broggi, Julie,Joubert, Nicolas,Díez-González, Silvia,Berteina-Raboin, Sabine,Zevaco, Thomas,Nolan, Steven P.,Agrofoglio, Luigi A.
, p. 1162 - 1170 (2009)
The synthesis of 1,2,3-triazolo-3′-deoxy-4′-hydroxymethyl carbanucleosides with different reaction conditions and diverse modulations on the heterocycle residues was developed. Heterocycle moieties were efficiently introduced on the pseudo-sugar either vi
Alkyne-azide click chemistry mediated carbanucleosides synthesis
Broggi, Julie,Joubert, Nicolas,Aucagne, Vincent,Berteina-Raboin, Sabine,Diez-Gonzalez,Nolan, Steve,Topalis, Dimitri,Deville-Bonne, Dominique,Balzarini, Jan,Neyts, Johan,Andrei, Graciela,Snoeck, Robert,Agrofoglio, Luigi A.
, p. 1391 - 1394 (2007)
Hitherto unknown 1,4-disubstituted-[1,2,3]-triazolo-4′,4′- dihydroxymethyl-3′-deoxy carbanucleosides were synthesized based on a "click approach." Various alkynes were introduced on a key azido intermediate by the "click" 1,3-dipolar Huisgen cycloaddition
Synthesis and antiviral evaluation of novel 5′-norcarboacyclic phosphonic acid nucleosides
Kim, Aihong,Hong, Joon
, p. 941 - 950 (2006)
This article describes a very simple route for synthesizing a novel 5′-norcarboacyclic nucleotides. The condensation of the mesylates 17 and 18 with the natural nucleosidic bases (A,U,T,C) under standard nucleophilic substitution (K 2 CO 3 , 18- Crown -6, DMF) and deprotection afforded the target nucleotide analogues 27-34 . In addition, these compounds were evaluated for their antiviral properties against various viruses. Copyright Taylor & Francis Group, LLC.
METHOD FOR CONJUGATING MOLECULES
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Paragraph 0106-0107, (2016/08/17)
Methods of conjugating two molecules are disclosed herein in which a non-polymeric aliphatic dialdehyde or non-polymeric aromatic dialdehyde is reacted with a compound comprising an amine (NH2) moiety to form a stable product under mild conditions.
Synthesis of 1,3-Cycloalkadienes from Cycloalkenes: Unprecedented Reactivity of Oxoammonium Salts
Nagasawa, Shota,Sasano, Yusuke,Iwabuchi, Yoshiharu
supporting information, p. 13189 - 13194 (2016/10/30)
Few methods allow for the direct conversion of cycloalkenes into cycloalkadienes with high chemo- and regioselectivity. Herein, we report a convenient one-pot process for this transformation that involves the unprecedented N-preferential group transfer of N-oxoammonium salts to cycloalkenes, followed by Cope elimination, to afford cycloalkadienes at room temperature and pressure.
PYRAZOLE DERIVATIVES AND USES THEREOF AS INHIBITORS OF DLK
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Page/Page column 120, (2015/07/07)
The present invention provides for compounds of formula 0 and various embodiments thereof, and compositions comprising compounds of formula 0 and various embodiments thereof. In compounds of formula 0, the groups R1A, R1B, R1C, R1D, R2, R3, R4, R5 and R6 have the meaning as described herein. The present invention also provides for methods of using compounds of formula 0 and compositions comprising compounds of formula 0 as DLK inhibitors and for treating neurodegeneration diseases and disorders.
SUBSTITUTED PYRAZOLES AND USES THEREOF
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Paragraph 0396; 397, (2015/07/02)
The present invention provides for compounds of formula 0 and various embodiments thereof, and compositions comprising compounds of formula 0 and various embodiments thereof. In compounds of formula 0, the groups R1A, R1B, R1C, R1D, R2, R3, R4, R5 and R6 have the meaning as described herein. The present invention also provides for methods of using compounds of formula 0 and compositions comprising compounds of formula 0 as DLK inhibitors and for treating neurodegeneration diseases and disorders.
COMPOUNDS FOR PROMOTING LIPOSOMAL AND CELLULAR ADHESION AND COMPOSITIONS AND METHODS OF USE THEREOF
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Paragraph 00254-00256, (2015/01/09)
The present application describes amphiphatic compounds like compound Ila below, compositions and methods for incorporating chemoselective and bio-orthogonal complementary functional groups into liposomes. Such compounds are incorporated in greater number
Simple synthesis and anti-HIV activity of novel cyclopentene phosphonate nucleosides
Kim, Aihong,Hong, Joon
, p. 1 - 8 (2007/10/03)
A very simple synthetic route for novel cyclopentene phosphonate nucleosides is described. The characteristic cyclopentene moiety 6 was constructed via a ring-closing metathesis of divinyl 5 , which could be readily prepared from diethylmalonate. The condensation of the mesylate 11 with nucleobases (A,C,T,U) under nucleophilic substitution conditions (K 2CO3, 18-Crown-6, DMF) afforded the target nucleosides 12 , 13 , 14 , and 15 . In addition, the antiviral evaluations against various viruses were performed. Copyright Taylor & Francis Group, LLC.
