769141-88-0Relevant academic research and scientific papers
Site-specific synthesis and properties of oligonucleotides containing C8-deoxyguanosine adducts of the dietary mutagen IQ
Elmquist, C. Eric,Stover, James S.,Wang, Zhiwei,Rizzo, Carmelo J.
, p. 11189 - 11201 (2007/10/03)
The site-specific synthesis of oligonucleotides containing the C8-deoxyguanosine adduct of the highly mutagenic heterocyclic amine 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) has been achieved, and the oligonucleotides were characterized by UV melting te
Synthesis of the C8-deoxyguanosine adduct of the food mutagen IQ.
Wang,Rizzo
, p. 565 - 568 (2007/10/03)
[structure: see text] The C8-2'-deoxyguanosine adduct of the food mutagen 2-amino-3-methylimadazo[4,5-f]-quinoline (IQ) has been synthesized. The key step is a palladium-catalyzed N-arylation of a suitably protected 8-bromo-2'-deoxyguanosine derivative.
