84283-08-9

Usage

Chemical Properties

Pale Yellow Solid

Uses

The DNA adduct of 4-Aminobiphenyl.

Upstream product

• 961-07-9 2'-Deoxyguanosine 
• 119273-48-2 N-(4-Biphenylyl)-O-pivaloylhydroxylamin 
• 243668-39-5 p-biphenylylnitrenium cation 
• 475473-90-6 N-(2'-deoxyguanosin-8-yl)-4-benzoylaminobiphenyl 
• 6810-26-0 4-hydroxylaminobiphenyl 
• 1124321-50-1 8N-(4-biphenylamino)-3',5'-bis(tert-butyldimethylsilyl)-2'-deoxyguanosine 
• 475473-89-3 N-acetoxy-N-benzoyl-4-amiobiphenyl 
• 866999-39-5 α-phenyl-N-(4-biphenyl)nitrone 
• 603994-28-1 6-benzyloxy-N⁸-biphenyl-4-yl-N²-[bis-(4-methoxy-phenyl)-phenyl-methyl]-9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-9H-purine-2,8-diamine 
• 919530-62-4 O⁶-benzyl-8N-(4-biphenylamino)-3',5'-bis(tert-butyldimethylsilyl)-2'-deoxy-guanosine 
• 328394-26-9 O⁶-benzyl-8-bromo-N9-[3',5'-O-(1,1,3,3-tetrakis(isopropyl)-1,3-disiloxanediyl)-β-D-2'-deoxyribofuranosyl]guanine 
• 769141-88-0 8-bromo-N9-[3',5'-O-(1,1,3,3-tetrakis(isopropyl)-1,3-disiloxanediyl)-β-D-2'-deoxyribofuranosyl]guanine 
• 13389-03-2 8-bromo-2'-deoxyguanosine 
• 92-93-3 1-phenyl-4-nitrobenzene 

Downstream Products

• 1125587-18-9 N₂-formamidino-8N-(4-biphenylamino)-2'-deoxyguanosine 

Relevant academic research and scientific papers

Synthesis of DNA strands site-specifically damaged by C8-arylamine purine adducts and effects on various DNA polymerases

C8-Arylamine-dG and C8-arylamine-dA adducts have been prepared using palladium cross-coupling chemistry. These adducts were subsequently converted into the corresponding 5′-O-DMTr-C8-arylamine-3′-O-phosphoramidites and then used for the automated synthesi

Synthesis of DNA-oligonucleotides damaged by arylamine-modified 2′-deoxyguanosine

C8-Arylamine-dG adducts bearing a labile N-formamidine group at the exocyclic amino function were converted into their corresponding 5′-O-DMTr-3′-O-phosphoramidite-C8-arylamine-dG derivatives. These compounds were used for the automated synthesis of site-

Quantification of N-(deoxyguanosin-8-yl)-4-aminobiphenyl adducts in human lymphoblastoid TK6 cells dosed with N-hydroxy-4-acetylaminobiphenyl and their relationship to mutation, toxicity, and gene expression profiling

Gene expression profiles that are anchored to phenotypic endpoints may lead to the identification of signatures that predict mutagenicity or carcinogenicity. The study presented here describes the analysis of DNA adducts in the human TK6 lymphoblastoid ce

Site-specific synthesis and properties of oligonucleotides containing C8-deoxyguanosine adducts of the dietary mutagen IQ

The site-specific synthesis of oligonucleotides containing the C8-deoxyguanosine adduct of the highly mutagenic heterocyclic amine 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) has been achieved, and the oligonucleotides were characterized by UV melting te

A practical approach for the chemical synthesis of 2′-deoxyguanosine-C8 adducts with mutagenic/carcinogenic amino- or nitro-arenes

Synthetic methods for the preparation of 2′-deoxyguanosine-C8 (dG-C8) adducts with several mutagenic and carcinogenic amino- or nitro-arenes were developed using the palladium-mediated cross-coupling reaction of protected 8-amino-dG with bromoarenes in ar

Synthesis and characterization of nucleoside derivatives, N-(benzoyl)-N-(deoxyguanosin-8-yl)-4-aminobiphenyl and N-(2′-deoxyguanosin-8-yl)-4-aminobiphenyl via α-phenyl-N-(4-biphenyl)nitrone

Lead tetraacetate (LTA) oxidation of α-Phenyl-N-(4-biphenyl)nitrone (8) to give a new ultimate carcinogen, N-acetoxy-N-benzoyl-4-aminobiphenyl (9) which was reacted with deoxyguanosine (dG) at pH 6.9 to give nucleoside derivative, N-(benzoyl)-N-(deoxyguan

Reactivity of the 4-biphenylyl and 2-fluorenylnitrenium ions with heterocyclic and carbon nucleophiles

The carcinogens 4-aminobiphenyl, 2-aminofluorene and their N-acetyl derivatives form DNA adducts in vivo with the aryl nitrogen attached at C-8 of guanine. These adducts are proposed to arise through the reaction with the DNA base of a nitrenium ion obtai