84283-08-9

Basic information

• Product Name: Guanosine, 8-((1,1'-biphenyl)-4-ylamino)-2'-deoxy-
• Synonyms: Guanosine, 8-((1,1'-biphenyl)-4-ylamino)-2'-deoxy-
• CAS NO: 84283-08-9
• Molecular Formula: C₂₂H₂₂N₆O₄
• Molecular Weight: 434.45
• Product Categories: Nucleotides;Bases & Related Reagents;Mutagenesis Research Chemicals
• Mol File: 84283-08-9.mol
• Article Data: 8

Chemical Properties

• Melting Point: 278°C dec.
• Appearance: /
• Density: 1.61±0.1 g/cm3(Predicted)
• Storage Temp.: -20°C Freezer
• PKA: 9.15±0.20(Predicted)
• CAS DataBase Reference: Guanosine, 8-((1,1'-biphenyl)-4-ylamino)-2'-deoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Guanosine, 8-((1,1'-biphenyl)-4-ylamino)-2'-deoxy-(84283-08-9)
• EPA Substance Registry System: Guanosine, 8-((1,1'-biphenyl)-4-ylamino)-2'-deoxy-(84283-08-9)

Safety Data

• Hazardous Substances Data: 84283-08-9(Hazardous Substances Data)

Usage

Chemical Properties

Pale Yellow Solid

Uses

The DNA adduct of 4-Aminobiphenyl.

Upstream product

• 1124321-50-1 8N-(4-biphenylamino)-3',5'-bis(tert-butyldimethylsilyl)-2'-deoxyguanosine 
• 475473-89-3 N-acetoxy-N-benzoyl-4-amiobiphenyl 
• 866999-39-5 α-phenyl-N-(4-biphenyl)nitrone 
• 603994-28-1 6-benzyloxy-N⁸-biphenyl-4-yl-N²-[bis-(4-methoxy-phenyl)-phenyl-methyl]-9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-9H-purine-2,8-diamine 
• 919530-62-4 O⁶-benzyl-8N-(4-biphenylamino)-3',5'-bis(tert-butyldimethylsilyl)-2'-deoxy-guanosine 
• 769141-96-0 O⁶-benzyl-8-[(1,1'-biphenyl)-4-ylamino]-N9-[3',5'-O-(1,1,3,3-tetrakis(isopropyl)-1,3-disiloxanediyl)-β-D-2'-deoxyribofuranosyl]guanine 
• 13389-03-2 8-bromo-2'-deoxyguanosine 
• 6810-26-0 4-hydroxylaminobiphenyl 
• 92-93-3 1-phenyl-4-nitrobenzene 
• 4075-79-0 4-phenylacetanilide 
• 961-07-9 2'-Deoxyguanosine 
• 769141-99-3 8-[(1,1'-biphenyl)-4-ylamino]-N9-[3',5'-O-(1,1,3,3-tetrakis(isopropyl)-1,3-disiloxanediyl)-β-D-2'-deoxyribofuranosyl]guanine 
• 475473-90-6 N-(2'-deoxyguanosin-8-yl)-4-benzoylaminobiphenyl 
• 243668-39-5 p-biphenylylnitrenium cation 

Downstream Products

• 1125587-18-9 N₂-formamidino-8N-(4-biphenylamino)-2'-deoxyguanosine 

Relevant articles and documents

Synthesis of DNA strands site-specifically damaged by C8-arylamine purine adducts and effects on various DNA polymerases

C8-Arylamine-dG and C8-arylamine-dA adducts have been prepared using palladium cross-coupling chemistry. These adducts were subsequently converted into the corresponding 5′-O-DMTr-C8-arylamine-3′-O-phosphoramidites and then used for the automated synthesi

Quantification of N-(deoxyguanosin-8-yl)-4-aminobiphenyl adducts in human lymphoblastoid TK6 cells dosed with N-hydroxy-4-acetylaminobiphenyl and their relationship to mutation, toxicity, and gene expression profiling

Gene expression profiles that are anchored to phenotypic endpoints may lead to the identification of signatures that predict mutagenicity or carcinogenicity. The study presented here describes the analysis of DNA adducts in the human TK6 lymphoblastoid ce

A practical approach for the chemical synthesis of 2′-deoxyguanosine-C8 adducts with mutagenic/carcinogenic amino- or nitro-arenes

Synthetic methods for the preparation of 2′-deoxyguanosine-C8 (dG-C8) adducts with several mutagenic and carcinogenic amino- or nitro-arenes were developed using the palladium-mediated cross-coupling reaction of protected 8-amino-dG with bromoarenes in ar