769169-71-3Relevant academic research and scientific papers
Practical asymmetric synthesis of trifluoromethyl-containing aminoester using a modified davis protocol
Alirnardanov, Asaf,Schmid, Jean,Afragola, Jay,Khafizova, Gulnaz
, p. 424 - 428 (2008)
Practical synthesis of aminoester 1 starting from 1,1,1-trifluoro-3- iodopropane is presented. Use of Ti(Oi-Pr)4 as a Lewis acid for condensation of intermediate aldehyde 8 with (S)-(+)-p-toluenesulfinamide was found to be critical. Conditions for a reproducible and high-yielding Wittig reaction of aldehyde hydrate with phosphorus ylide 4, that appear to have general applicability, are described.
