769169-80-4

Upstream product

• 1029042-32-7 C₁₃H₁₃NOF₆S 
• 5804-85-3 diethylaluminium cyanide 
• 769169-74-6 4,4,4-trifluoro-2-(2,2,2-trifluoroethyl)butyraldehyde 
• 188447-91-8 (S)-p-toluenesulfinimide 
• 952714-30-6 4,4,4-trifluoro-N-methoxy-N-methyl-2-(2,2,2-trifluoroethyl)butyramide 
• 769169-71-3 4,4,4-trifluoro-2-(2,2,2-trifluoroethyl)-but-2-enoic acid ethyl ester 
• 769169-73-5 4,4,4-Trifluoro-2-(2,2,2-trifluoroethyl)-butan-1-ol 
• 769169-72-4 4,4,4-trifluoro-2-(2,2,2-trifluoroethyl)butyric acid ethyl ester 

Relevant academic research and scientific papers

Practical asymmetric synthesis of trifluoromethyl-containing aminoester using a modified davis protocol

Practical synthesis of aminoester 1 starting from 1,1,1-trifluoro-3- iodopropane is presented. Use of Ti(Oi-Pr)4 as a Lewis acid for condensation of intermediate aldehyde 8 with (S)-(+)-p-toluenesulfinamide was found to be critical. Conditions for a reproducible and high-yielding Wittig reaction of aldehyde hydrate with phosphorus ylide 4, that appear to have general applicability, are described.

Asymmetric synthesis of novel α-amino acids with β-branched side chains

An asymmetric synthesis of α-amino acids with novel β-branched side chains has been implemented. The syntheses feature a p-toluenesulfinylimine induced chiral Strecker approach and were found to be applicable to the introduction of both aliphatic and aromatic β-branched sidechains for preparation of previously unknown α-amino acids.