7692-57-1

Usage

Uses

Used in Pharmaceutical Industry:
6-CHLORO-2-(METHYLTHIO)-1H-BENZO[D]IMIDAZOLE is used as a pharmaceutical agent for its potential anti-inflammatory properties, helping to reduce inflammation and alleviate symptoms associated with various inflammatory conditions.
Used in Oncology:
In the field of oncology, 6-CHLORO-2-(METHYLTHIO)-1H-BENZO[D]IMIDAZOLE is used as an anticancer agent, being studied for its potential to target and inhibit the growth of cancer cells, making it a promising candidate for the development of novel cancer therapies.
Used in Microbiology:
6-CHLORO-2-(METHYLTHIO)-1H-BENZO[D]IMIDAZOLE is used as an antimicrobial agent, exhibiting properties that can help combat microbial infections, including bacteria and fungi, and contribute to the development of new antimicrobial drugs.
Used in Organic Synthesis:
6-CHLORO-2-(METHYLTHIO)-1H-BENZO[D]IMIDAZOLE is used as a building block in the synthesis of various organic compounds, playing a crucial role in the development of new chemical entities with diverse applications across different industries.

InChI:InChI=1/C8H7ClN2S/c1-12-8-10-6-3-2-5(9)4-7(6)11-8/h2-4H,1H3,(H,10,11)

Upstream product

• 25369-78-2 5-chloro-1H-benzoimidazole-2-thiol 
• 74-88-4 methyl iodide 
• 25369-78-2 5-chloro-1,3-dihydro-2H-benzo[d]imidazole-2-thione 
• 95-83-0 4-Chloro-1,2-phenylenediamine 

Relevant academic research and scientific papers

NOVEL 2-SUBSTITUTED IMIDAZOLE COMPOUND AND USE THEREOF

An object of the present invention is to provide novel 2-substituted imidazole compounds or salts thereof that have pesticidal activity. The present invention provides a 2-substituted imidazole compounds represented by Formula (1) : or a salt thereof, wherein R1, R2, and R3are identical or different and each represent hydrogen, or C1-C4-haloalkyl; R4represents (1) hydrogen or a substituent as defined herein, R5represents C1-12alkyl or other substituents as defined herein, A represents NR6, O or S(O)m, m = 0, 1 or 2, W, X, Y, and Z are identical or different and each represent CR4or N, R6 is C1-12 alkyl or a substituent as defined herein, and n is an integer of 1 to 4.

Synthesis and antiparasitic activity of 1H-benzimidazole derivatives.

Compounds 1-18 have been synthesized and tested in vitro against the protozoa Giardia lamblia, Entamoeba histolytica and the helminth Trichinella spiralis. Inhibition of rat brain tubulin polymerization was also measured and compared for each compound. Results indicate that most of the compounds tested were more active as antiprotozoal agents than Metronidazole and Albendazole. None of the compounds was as active as Albendazole against T. spiralis. Although only compounds 3, 9 and 15 (2-methoxycarbonylamino derivatives) inhibited tubulin polymerization, these were not the most potent antiparasitic compounds.