76929-42-5

Basic information

• Product Name: 5-CHLORO-4-METHOXY-2-PHENYL-3(2H)-PYRIDAZINONE
• Synonyms: 5-CHLORO-4-METHOXY-2-PHENYL-3(2H)-PYRIDAZINONE;5-chloro-4-methoxy-2-phenyl-2,3-dihydropyridazin-3-one
• CAS NO: 76929-42-5
• Molecular Formula: C₁₁H₉ClN₂O₂
• Molecular Weight: 236.65
• Mol File: 76929-42-5.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-CHLORO-4-METHOXY-2-PHENYL-3(2H)-PYRIDAZINONE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-CHLORO-4-METHOXY-2-PHENYL-3(2H)-PYRIDAZINONE(76929-42-5)
• EPA Substance Registry System: 5-CHLORO-4-METHOXY-2-PHENYL-3(2H)-PYRIDAZINONE(76929-42-5)

Safety Data

• Hazardous Substances Data: 76929-42-5(Hazardous Substances Data)

Upstream product

• 1698-53-9 4,5-dichloro-1-phenylpyridazin-6-one 
• 124-41-4 sodium methylate 

Downstream Products

• 335349-30-9 4-methoxy-2-phenyl-5-(3-thienyl)-3(2H)-pyridazinone 
• 335349-29-6 4-methoxy-5-(4-methoxyphenyl)-2-phenyl-3(2H)-pyridazinone 

Relevant articles and documents

Discovery and structure-activity relationship analysis of Staphylococcus aureus sortase A inhibitors

Methicillin resistant Staphylococcus aureus (MRSA) is a major health problem that has created a pressing need for new antibiotics. Compounds that inhibit the S. aureus SrtA sortase may function as potent anti-infective agents as this enzyme attaches virulence factors to the cell wall. Using high-throughput screening, we have identified several compounds that inhibit the enzymatic activity of the SrtA. A structure-activity relationship (SAR) analysis led to the identification of several pyridazinone and pyrazolethione analogs that inhibit SrtA with IC50 values in the sub-micromolar range. Many of these molecules also inhibit the sortase enzyme from Bacillus anthracis suggesting that they may be generalized sortase inhibitors.