76931-93-6

Basic information

• Product Name: SATA
• Synonyms: n-hydroxysuccinimides-acetylthioacetate;SUCCINIMIDYL ACETYLTHIOACETATE;SATA;S-ACETYLTHIOGLYCOLIC ACID NHS ESTER;S-ACETYLTHIOGLYCOLIC ACID N-HYDROXYSUCCINIMIDE ESTER;S-ACETYLTHIOGLYCOLIC ACID N-SUCCINIMIDYL ESTER;S-ACETYLTHIOACETIC ACID-N-HYDROXYSUCCINIMIDE ESTER;N-SUCCINIMIDYL (ACETYLTHIO)ACETATE
• CAS NO: 76931-93-6
• Molecular Formula: C₈H₉NO₅S
• Molecular Weight: 231.23
• EINECS: 678-479-6
• Product Categories: MTS and Sulfhydryl Active Reagents;N-Substituted Maleimides, Succinimides & Phthalimides;N-Substituted Succinimides;MTS & Sulfhydryl Active Reagents;Building Blocks;Chemical Biology;Chemical Synthesis;Crosslinkers;Crosslinking;Heterobifunctional Cross-Linking Reagents;Linkers and Crosslinkers;Organic Building Blocks;Protected Thiols/Mercaptans;Protein Modification;Protein Structural Analysis;Proteomics;Sulfur Compounds;Heterocycles;Protein Modification Reagents;proteinmod
• Mol File: 76931-93-6.mol
• Article Data: 4

Chemical Properties

• Melting Point: 84-89 °C
• Boiling Point: 337.3 °C at 760 mmHg
• Flash Point: 157.8 °C
• Appearance: /powder
• Density: 1.46 g/cm,sup>3
• Vapor Pressure: 0.000106mmHg at 25°C
• Refractive Index: 1.561
• Storage Temp.: −20°C
• Solubility: acetonitrile: 50 mg/mL
• Stability: Moisture Sensitive
• BRN: 7815491
• CAS DataBase Reference: SATA(CAS DataBase Reference)
• NIST Chemistry Reference: SATA(76931-93-6)
• EPA Substance Registry System: SATA(76931-93-6)

Safety Data

• Safety Statements: 25/26
• WGK Germany: 3
• F: 3-10-23
• Hazardous Substances Data: 76931-93-6(Hazardous Substances Data)

Usage

Chemical Properties

White to Off-White Solid

Uses

Different sources of media describe the Uses of 76931-93-6 differently. You can refer to the following data:
1. N-Succinimidyl S-Acetylthioglycolate can be used as Thiolating reagent for primary amines; thiol can be deprotected under mild conditions and be useful for preparation of enzyme immunoconjugates and hapten carrier molecule conjugates.
2. Thiolating reagent for primary amines; thiol can be deprotected under mild conditions. Typically, couples initially to a molecule containing primary amine by amide bond buffered at pH 7.5. Deprotection may be accomplished with 0.05 M hydroxylamine at neutral pH. Useful for preparation of enzyme immunoconjugates and hapten carrier molecule conjugates.
3. Reacts with primary amines to add protected sulfhydryls.

InChI:InChI=1/C8H9NO5S/c1-5(10)15-4-8(13)14-9-6(11)2-3-7(9)12/h2-4H2,1H3

Upstream product

• 6066-82-6 1-hydroxy-pyrrolidine-2,5-dione 
• 1190-93-8 (Acetylthio)acetic acid 

Downstream Products

• 853029-16-0 C₁₄H₁₇NO₄S 

Relevant articles and documents

A superparamagnetic iron oxide nano MRI probe and its preparation method and application thereof

The invention relates to a superparamagnetic iron oxide nano MRI (magnetic resonance imaging) probe and a preparation method and application thereof. A chemical formula of the superparamagnetic iron oxide nano MRI probe is shown in the specification, wherein SPIO refers to superparamagnetic iron oxide, CTX refers to scorpion chloride toxins, and n refers to degree of polymerization and is an arbitrary integer from 4 to 200. The novel superparamagnetic iron oxide nano MRI probe is prepared successfully, a magnetic resonance imaging law of a nanoparticle solution of the MRI probe is identical to that of an SPIO solution, and the magnetic resonance imaging law refers to that along with increase of concentration of iron in the solution, signal intensity of a T1WI sequence is increased, and signal intensity of a T2WI sequence is reduced. The superparamagnetic iron oxide nano MRI probe has no evident cytotoxicity to human hepatocellular carcinoma cell line HepG2 and can be used for early detection of hepatocellular carcinoma.

Gold Nanoparticles Decorated with Sialic Acid Terminated Bi-antennary N-Glycans for the Detection of Influenza Virus at Nanomolar Concentrations

Gold nanoparticles decorated with full-length sialic acid terminated complex bi-antennary N-glycans, synthesized with glycans isolated from egg yolk, were used as a sensor for the detection of both recombinant hemagglutinin (HA) and whole influenza A virus particles of the H1N1 subtype. Nanoparticle aggregation was induced by interaction between the sialic acid termini of the glycans attached to gold and the multivalent sialic acid binding sites of HA. Both dynamic light scattering (DLS) and UV/Vis spectroscopy demonstrated the efficiency of the sensor, which could detect viral HA at nanomolar concentrations and revealed a linear relationship between the extent of nanoparticle aggregation and the concentration of HA. UV/Vis studies also showed that these nanoparticles can selectively detect an influenza A virus strain that preferentially binds sialic acid terminated glycans with α(2→6) linkages over a strain that prefers glycans with terminal α(2→3)-linked sialic acids.