76945-00-1Relevant academic research and scientific papers
Total Synthesis of Camptothecin and Related Natural Products by a Flexible Strategy
Li, Ke,Ou, Jinjie,Gao, Shuanhu
supporting information, p. 14778 - 14783 (2016/11/23)
A flexible strategy for constructing natural products containing indolizinone or quinolizinone scaffolds and their analogues was developed, which was based on a cascade exo hydroamination followed by spontaneous lactamization. This method was applied in the total synthesis of camptothecin in nine steps in a new ring-forming approach. It was also used to efficiently prepare five biogenetically or structurally related natural alkaloids, including 22-hydroxyacuminatine, oxypalmatine, norketoyobyrine, naucleficine, and nauclefine, as well as 35 natural-product-like molecules. We believe that this method and the small-molecule library prepared with it can open new avenues for studying the bioactivity of camptothecin and Nauclea natural products.
REISSERT COMPOUND STUDIES. XXXVIII. PRELIMINARY OBSERVATIONS ON 3,4-DIHYDRO-β-CARBOLINE
Popp, Frank D.,Veeraraghavan, Seshadri
, p. 481 - 482 (2007/10/02)
3,4-Dihydro-β-carboline and its 9-benzyl derivative have been converted to Reissert compounds.The anion of these Reissert compounds has been alkylated with methyl iodide.A compound with great potential as an intermediate in the synthesis of indole alkaloid systems has been prepared by treatment of the Reissert compound formed from 9-benzyl-3,4-dihydro-β-carboline and 2-chloromethylbenzoyl chloride with sodium hydride.
Reissert Compound Studies. XLII. Synthesis and Reactions of the 3,4-Dihydro-β-carboline Reissert Compound and Observations on α, β, and γ-Carbolines
Veeraraghavan, Seshardi,Popp, Frank D.
, p. 909 - 915 (2007/10/02)
3,4-Dihydro-β-carboline and benzo-γ-carboline yielded Reissert compounds.The 3,4-dihydro-β-carboline Reissert compound, through its acid- and base-promoted reactions, was found to be a very useful intermediate in the synthesis of several β-carboline de
