76980-62-6Relevant academic research and scientific papers
Ruthenium-catalyzed meta/ortho-selective C-H alkylation of azoarenes using alkyl bromides
Li, Gang,Ma, Xingxing,Jia, Chunqi,Han, Qingqing,Wang, Ya,Wang, Junjie,Yu, Liuyang,Yang, Suling
, p. 1261 - 1264 (2017/02/05)
meta/ortho-Selective CAr-H (di)alkylation reactions of azoarenes have been achieved via [Ru(p-cymene)Cl2]2 catalyzed ortho-metalation using various types of alkyl bromides. Particularly, dual meta-alkylation of azoarene and reduction offer an attractive strategy for the synthesis of meta-alkylanilines, which are difficult to access via traditional aniline functionalization methods.
Nonsteroidal antiinflammatory agents. 2. [(Heteroarylamino)phenyl]alkanoic acids
Hino,Nakamura,Nagai,Uno,Nishimura
, p. 222 - 226 (2007/10/02)
A series of [(heteroarylamino)phenyl]alkanoic acids pyridine, quinoline, or pyrimidine as the heteroaryl moiety was prepared as potential antiinflammatory agents. Among them, 2-[4-(2-pyridylamino)phenyl]propionic acid (14b) showed excellent antiinflammatory and analgesic activities with less tendency to cause gastric side effects. Structure-activity relationships are discussed.
