21762-10-7Relevant academic research and scientific papers
Visible Light-Driven Carboxylation of Olefins by Using 2D Metal-Free Covalent Organic Framework as Intrinsic Photocatalyst: A Sustainable Approach for CO2 Utilization
Das, Anjan,Ghosh, Swarbhanu,Manirul Islam, Sk.,Sarkar, Priyanka
, (2022/05/20)
Photocatalytic metal-free carboxylation of olefins offers an environment-friendly approach for resolving the increasing energy issue as well as mitigating the dilemma caused by the greenhouse effect. Carboxylation of styrene and its derivatives by photocatalytic CO2 reduction reaction shows great potential for sustainable utilization of greenhouse gas CO2 into valuable chemicals. Herein, we have constructed a highly crystalline and thermally stable 2D porous covalent organic framework (COF) having very low band-gap energy, 1.8 eV and it shows efficient photocatalytic activity towards the carboxylation of aryl-alkenes in good yields in presence of p-terphenyl as a co-catalyst at ambient temperature under visible light irradiation and 1 atmospheric CO2 pressure which facilitates to overcome the current transition metal catalyzed approaches. In addition, TR-OT COF is a proficient and highly selective catalyst with outstanding recyclability. This suggests that this COF material is a novel photocatalyst for CO2 reduction towards α, β-carboxylation of styrene and its derivatives under 20 W light-emitting diode (LED) light.
Palladium-Catalyzed α-Arylation of Carboxylic Acids and Secondary Amides via a Traceless Protecting Strategy
He, Zhi-Tao,Hartwig, John F.
supporting information, p. 11749 - 11753 (2019/08/26)
A novel traceless protecting strategy is presented for the long-standing challenge of conducting the palladium-catalyzed α-arylation of carboxylic aids and secondary amides with aryl halides. Both of the presented coupling processes occur with a variety of carboxylic acids and amides and with a variety of aryl bromides containing a broad range of functional groups, including base-sensitive functionality like acyl, alkoxycarbonyl, nitro, cyano, and even hydroxyl groups. Five commercial drugs were prepared through this method in one step in 81-96% yield. Gram-scale synthesis of medication Naproxen and Flurbiprofen with low palladium loading further highlights the practical value of this method.
Aniline derivatives possessing an inhibitory effect of nitric oxide synthase
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, (2008/06/13)
Compounds represented by the general formula (1): ? (where R1is SR6or NR7R8, where R6is typically an alkyl group having 1-6 carbon atoms, R7is a hydrogen atom, an alkyl group having 1-6 carbon atoms or a nitro group, and R8is a hydrogen atom or an alkyl group having 1-6 carbon atoms; R2and R3are each typically a hydrogen atom or an alkyl group having 1-6 carbon atoms; R4is a hydrogen atom, an alkyl group having 1-6 carbon atoms or an amidino group of which the amine portion may be substituted by an alkyl or nitro group; R5is a hydrogen atom or an alkyl group having 1-6 carbon atoms; Y1, Y2, Y3and Y4which may be the same or different are each typically a hydrogen atom, a halogen atom or an alkoxy group having 1-6 carbon atoms; n and m are each an integer of 0 or 1), or possible stereoisomers or optically active forms of the compounds or pharmaceutically acceptable salts thereof. The compounds possess a potent nitric oxide synthase inhibiting activity and are useful as therapeutics of cerebrovascular diseases.
Experiments on the Chaperon effect in the nitration of aromatics
Strazzolini, Paolo,Giumanini, Angelo G.,Runcio, Antonio,Scuccato, Massimo
, p. 952 - 958 (2007/10/03)
A nitro group may be effectively delivered to the ortho position of alkylbenzenes, provided that a suitable chaperon function is located in α- position and a dilute of HNO3 in CH2Cl2 is used. The carbonyl function of an aldehyde or ketone is the best choice, but a carboxyl, alkoxycarbonyl, and amide groups all work well. The ether function showed a less pronounced ortho orientation effect, whereas the hydroxyl group was too prone to oxidation. Side reactions were minimal under the conditions employed. A para chaperon effect was seemingly at work in the CH2Cl2 nitration of benzenepropanenitrile. All the results were compared with the corresponding classical nitration in H2SO4.
Process for the preparation of nitrobenzene derivatives
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, (2008/06/13)
A method for preparing a compound of formula (I), wherein R1 and R2, which are the same or different, are a hydrogen atom or an alkyl or alkoxy radical, or R1 and R2, taken together with the carbon atom to which
Thiazolidine derivatives, preparation thereof and drugs containing samem
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, (2008/06/13)
Derivatives of formula (I), their salts, the preparation of said derivatives and drugs containing same. The compounds of formula (I) have interesting pharmacological properties. Said compounds have a high affinity for cholecystokinin (CCK) and gastrin rec
Pyrrolidine and thiazolidine derivatives, their preparation and medicaments containing them
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, (2008/06/13)
This invention relates to compositions of formula: STR1 and their salts, their preparation and the medicaments containing them.
Convenient syntheses of racemic 2-(3-nitrophenyl)propanoic acid and 2-(3-aminophenyl)propanoic acid
Grondard, Luc,Manfre, Franco,Mutti, Stephane
, p. 425 - 430 (2007/10/03)
2-(4-Chlorophenyl)propanoic acid 1 is transformed to 2-(4-chloro-3-nitrophenyl)propanoic acid 2 (94% yield). Acid 2 can be converted to 2-(3-nitrophenyl)propanoic acid 3 (70% yield) or to 2-(3-aminophenyl)propanoic acid 4 (80% yield).
