76982-22-4

Upstream product

• 108-24-7 acetic anhydride 
• 5037-75-2 cyclo(Gly-Phe) 
• 7625-57-2 methyl 2-((2S)-2-((tert-butoxycarbonyl)amino)-3-phenylpropanamido)acetate 
• 65559-51-5 L-Phenylalaninyl-glycine methyl ester 
• 30166-29-1 1-acetyl-3-[(Z)-benzylidene]-2,5-piperazinedione 
• 3027-05-2 N,N'-diacetylpiperazin-2,5-dione 

Downstream Products

• 1235977-31-7 t-butyl-3-[(3S)-(Z)-(5-benzyl-3,6-dioxopiperazin-2-ylidene)methyl]-4-nitroindole-1-carboxylate 
• 1235977-30-6 t-butyl-3-[(3S)-(Z)-(4-acetyl-5-benzyl-3,6-dioxopiperazin-2-ylidene)methyl]-4-nitroindole-1-carboxylate 
• 1092687-10-9 1-acetyl-6-benzyl-3-(2-bromobenzylidene)piperazine-2,5-dione 
• 77027-33-9 4-acetyl-(S)-3-benzyl-(E)-6-benzylidene-2,5-piperazinedione 
• 117249-51-1 (R)-3-benzyl-(Z)-6-benzylidene-2,5-piperazinedione 
• 77027-29-3 4-acetyl-(S)-3-benzyl-(Z)-6-benzylidene-2,5-piperazinedione 

Relevant academic research and scientific papers

Histamine H3 receptor antagonists with peptidomimetic (keto)piperazine structures to inhibit Aβ oligomerisation

Alzheime?s disease (AD) is the most prominent neurodegenerative disorder with high medical need. Protein-protein-interactions (PPI) interactions have a critical role in AD where β-amyloid structures (Aβ) build toxic oligomers. Design of disease modifying multi target directed ligand (MTDL) has been performed, which disable PPI on the one hand and on the other hand, act as procognitive antagonists at the histamine H3 receptor (H3R). The synthetized compounds are structurally based on peptidomimetic amino acid-like structures mainly as keto, diketo-, or acyl variations of a piperazine moiety connected to an H3R pharmacophore. Most of them showed low nanomolar affinities at H3R and some with promising affinity to Aβ-monomers. The structure–activity relationships (SAR) described offer new possibilities for MTDL with an optimized profile combining symptomatic and potential causal therapeutic approaches in AD.

Synthesis and phytotoxicity of structural analogues of thaxtomin natural products

Structural analogues of the phytotoxic thaxtomin natural products have been synthesized by building upon a piperazinedione core and from l-phenylalanine. The compounds were evaluated for their phytotoxic activity against Arabidopsis thaliana seedlings and some of the key features for activity have been identified. CSIRO 2010.

Herbicidally Active Composition

The present invention relates to herbicidally active compositions comprising at least one piperazinedione compound of the formula I in which: Rx, Ry are each hydrogen or together are a chemical bond; R1 is cyano or nitro; R2 is hydrogen, fluorine, chlorine, C1-C2-alkyl, ethenyl or C1-C2-alkoxy; R3 is fluorine or hydrogen; R4 is methyl; R5 is hydrogen, methyl or ethyl; R6 is hydrogen, methyl or ethyl; and R7 is hydrogen or halogen; and at least one further active compound selected from the group consisting of b1) lipid biosynthesis inhibitors; b2) acetolactate synthase inhibitors (ALS inhibitors); b3) photosynthesis inhibitors; b4) protoporphyrinogen-IX oxidase inhibitors, b5) bleacher herbicides; b6) enolpyruvyl shikimate 3-phosphate synthase inhibitors (EPSP inhibitors); b7) glutamine synthetase inhibitors; b8) 7,8-dihydropteroate synthase inhibitors (DHP inhibitors); b9) mitose inhibitors; b10) inhibitors of the synthesis of very long chain fatty acids (VLCFA inhibitors); b11) cellulose biosynthesis inhibitors; b12) decoupler herbicides; b13) auxin herbicides; b14) auxin transport inhibitors; b15) other herbicides, and C) safeners.

Phenylahistin and the phenylahistin analogs, a new class of anti-tumor compounds

A compound, its pharmaceutically acceptable salts, and/or its pro-drug esters, in isolated form, and methods for isolating, for formulating, and for administering the compound, salt, and/or pro-drug ester as an antitumor agent, wherein the compound, salt,

Synthesis and biological activities of phenylahistin derivatives

X-ray crystallographic analysis was performed and several phenylahistin derivatives were synthesized to elucidate the structural components necessary for the anti-microtubule activity of phenylahistin. We primarily focused on the unique isoprenylated dehy

SYNTHESIS AND STRUCTURAL ASSIGNMENT OF NATURALLY OCCURRING 3-BENZYL-6-BENZYLIDENE-2,5-PIPERAZINEDIONE

Four possible stereoisomers of 3-benzyl-6-benzylidene-2,5-piperazinedione were synthesized, and the configuration of the natural product isolated from Streptomyces noursei was determined to be (3R, 6Z).It was found that the sign of the optical rotations and the Cotton effect are reversed only by the difference of the (E)- or (Z)-geometry.