75404-00-1

Basic information

• Product Name: (5S,6R)-8-Oxo-5-(3,4,5-trimethoxy-phenyl)-5,6,7,8-tetrahydro-naphtho[2,3-d][1,3]dioxole-6-carboxylic acid ethyl ester
• CAS NO: 75404-00-1
• Molecular Weight: 428.439
• Mol File: 75404-00-1.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: (5S,6R)-8-Oxo-5-(3,4,5-trimethoxy-phenyl)-5,6,7,8-tetrahydro-naphtho[2,3-d][1,3]dioxole-6-carboxylic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (5S,6R)-8-Oxo-5-(3,4,5-trimethoxy-phenyl)-5,6,7,8-tetrahydro-naphtho[2,3-d][1,3]dioxole-6-carboxylic acid ethyl ester(75404-00-1)
• EPA Substance Registry System: (5S,6R)-8-Oxo-5-(3,4,5-trimethoxy-phenyl)-5,6,7,8-tetrahydro-naphtho[2,3-d][1,3]dioxole-6-carboxylic acid ethyl ester(75404-00-1)

Safety Data

• Hazardous Substances Data: 75404-00-1(Hazardous Substances Data)

Upstream product

• 134302-94-6 3-ethyl 2-methyl rel-(2R,3S,4R)-6,7-methylenedioxy-1-oxo-4-(3,4,5-trimethoxyphenyl)-1,2,3,4-tetrahydronaphthalene-2,3-dicarboxylate 
• 64-17-5 ethanol 
• 25054-53-9 3,4-(methylenedioxy)benzoyl chloride 
• 75404-00-1 ethyl rel-(3R,4R)-6,7-methylenedioxy-1-oxo-4-(3,4,5-trimethoxyphenyl)-1,2,3,4-tetrahydronaphthalene-3-carboxylate 
• 134310-05-7 4-ethyl 3-methyl rel-(3R,4S,5S)-2-oxo-3-piperonyloyl-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran-3,4-dicarboxylate 
• 134302-93-5 4-ethyl 3-methyl rel-(3R,4S,5S)-2-oxo-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran-3,4-dicarboxylate 
• 1878-29-1 ethyl (E)-3-(3,4,5-trimethoxyphenyl)acrylate 
• 75403-99-5 ethyl 2-(3,4-methylenedioxybenzoyl)-3-(3,4,5-trimethoxyphenyl)-cyclopropanecarboxylate 
• 75403-99-5 ethyl 2-(3,4-methylenedioxybenzoyl)-3-(3,4,5-trimethoxyphenyl)-cyclopropanecarboxylate 
• 75403-99-5 (2S,3S)-2-(Benzo[1,3]dioxole-5-carbonyl)-3-(3,4,5-trimethoxy-phenyl)-cyclopropanecarboxylic acid ethyl ester 
• 76985-19-8 ethyl 2-(3,4-methylenedioxybenzoyl)-3-(3,4,5-trimethoxyphenyl)-cyclopropanecarboxylate 
• 88775-47-7 (2E)-1-(2H-benzo[3,4-d]1,3-dioxolan-5-yl)-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one 

Downstream Products

• 75404-00-1 (5S,6R)-8-Oxo-5-(3,4,5-trimethoxy-phenyl)-5,6,7,8-tetrahydro-naphtho[2,3-d][1,3]dioxole-6-carboxylic acid ethyl ester 
• 106044-41-1 (5S,6R)-5-(3,4,5-Trimethoxy-phenyl)-5,6-dihydro-naphtho[2,3-d][1,3]dioxole-6-carboxylic acid benzhydryl ester 
• 106044-41-1 (5S,6S)-5-(3,4,5-Trimethoxy-phenyl)-5,6-dihydro-naphtho[2,3-d][1,3]dioxole-6-carboxylic acid benzhydryl ester 
• 477-47-4 (+/-) epipodophyllotoxin 
• 106044-46-6 (3aS,4R,5R,10bS)-3-Bromo-5-(3,4,5-trimethoxy-phenyl)-3a,4,5,10b-tetrahydro-1,7,9-trioxa-2-aza-dicyclopenta[a,g]naphthalene-4-carboxylic acid benzhydryl ester 
• 106044-47-7 (3aR,4S,5S,10bR)-3-Chloro-5-(3,4,5-trimethoxy-phenyl)-3a,4,5,10b-tetrahydro-1,7,9-trioxa-2-aza-dicyclopenta[a,g]naphthalene-4-carboxylic acid 
• 106044-49-9 (5S,6S,7S,8R)-7-Cyano-8-hydroxy-5-(3,4,5-trimethoxy-phenyl)-5,6,7,8-tetrahydro-naphtho[2,3-d][1,3]dioxole-6-carboxylic acid 
• 104715-48-2 (5S,6S,7S,8R)-7-Aminomethyl-8-hydroxy-5-(3,4,5-trimethoxy-phenyl)-5,6,7,8-tetrahydro-naphtho[2,3-d][1,3]dioxole-6-carboxylic acid 
• 100146-47-2 (5R,6R)-8-Hydroxy-5-(3,4,5-trimethoxy-phenyl)-5,6,7,8-tetrahydro-naphtho[2,3-d][1,3]dioxole-6-carboxylic acid 
• 106044-42-2 (5R,6R)-5-(3,4,5-Trimethoxy-phenyl)-5,6-dihydro-naphtho[2,3-d][1,3]dioxole-6-carboxylic acid 
• 1456-54-8 (+/-)-neopodophyllotoxin 
• 112026-15-0 (5S,6S,7S,8S)-7-Benzyloxymethyl-8-hydroxy-5-(3,4,5-trimethoxy-phenyl)-5,6,7,8-tetrahydro-naphtho[2,3-d][1,3]dioxole-6-carboxylic acid ethyl ester 
• 112026-13-8 (5S,6S,7S)-7-Benzyloxymethyl-8-oxo-5-(3,4,5-trimethoxy-phenyl)-5,6,7,8-tetrahydro-naphtho[2,3-d][1,3]dioxole-6-carboxylic acid ethyl ester 
• 112026-14-9 C₂₉H₂₈O₈ 

Relevant articles and documents

Syntheses of (±)-thuriferic acid ethyl ester, its analogues and (±)-picropodophyllone

(±)-Thuriferic acid ethyl ester, its analogues as well as (±)-picropodophyllone have been prepared. The synthetic strategy is based on the utility of vicinal dianions derived from α-aroylsuccinic esters.

TOTAL SYNTHESIS OF (+/-) PODOPHYLLOTOXIN

A straightforward approach to podophyllotoxin was developed using silyl enol ether 5.

Total Synthesis of ( +/-)-Picropodophillone

Following model studies, the synthesis of (+/-)-picropodophillone was completed by first cyclopropanating the appropriate chalcone (11) with ethoxycarbonyl dimethylsulphonium methylide.Treatment of the resulting cyclopropyl ketone with stannic chloride in