769939-13-1Relevant academic research and scientific papers
3-Thiolated pyrroles/pyrrolines: controllable synthesis and usage for the construction of thiolated fluorophores
Tian, Jun,Yuan, Kang-Ning,Liu, Wen,Chang, Hong-Hong,Li, Xing,Gao, Wen-Chao
, p. 1943 - 1946 (2021)
Thiolation/cyclization of homopropargylic tosylamides allowed the selective synthesis of 3-thiolated pyrroles and pyrrolines controlled by solvents. Moreover, the desired 3-thiolated pyrroles were readily transformed to organic fluorophores benzothienopyrrole and bisthiolated boron dipyrromethene (S-BODIPY).
An efficient ring-opening reaction of aziridines with alkynes catalyzed by CuOTf
Ding, Chang-Hua,Dai, Li-Xin,Hou, Xue-Long
, p. 1691 - 1694 (2004)
The alkynylation of activated aziridines in the presence of a catalytic amount of CuOTf provided the corresponding ring-opened products in high yields.
TMSOTf mediated '5/6-: Endo-dig ' reductive hydroamination for the stereoselective synthesis of pyrrolidine and piperidine derivatives
Gharpure, Santosh J.,Vishwakarma, Dharmendra S.,Patel, Raj K.
supporting information, p. 6858 - 6861 (2019/06/18)
A TMSOTf mediated 5/6-endo-dig reductive hydroamination cascade on internal alkynylamines gave expedient, stereoselective access to pyrrolidine and piperidine derivatives. We also demonstrate that a protecting group on nitrogen has a profound effect on the reactivity as well as diastereoselectivity of the reductive hydroamination cascade.
Rhodium(III)-catalyzed oxidative bicyclization of 4-arylbut-3-yn-1-amines with internal alkynes through C-H functionalization
Pi, Rui,Zhou, Ming-Bo,Yang, Yuan,Gao, Cai,Song, Ren-Jie,Li, Jin-Heng
, p. 13550 - 13553 (2015/09/01)
A new Rh(III)-catalyzed oxidative bicyclization through C-H functionalization is presented. This reaction allows the selective assembly of diverse benzo[g]indoles from 4-arylbut-3-yn-1-amines and internal alkynes via a sequence of aromatic C(sp2)-H functionalization, cyclodimerization and nucleophilic cyclization.
A convenient and efficient ring-opening reaction of aziridines with acetylenes and synthesis of dihydropyrroles
Ding, Chang-Hua,Dai, Li-Xin,Hou, Xue-Long
, p. 9586 - 9593 (2007/10/03)
In the presence of BuOK, reaction of acetylenes with N-Ts substituted aziridines derived from both cyclic and acyclic alkenes at room temperature gave rise to homopropargylamines in good to high yields and in high regioselectivity. Not only Ph- and Me3Si-substituted acetylenes but also acetylene itself was suitable reagents. Treatment of ring-opening products with I2 and AgOAc in the presence of K2CO3 provided dihydropyrroles in high yields. One-pot synthesis of dihydropyrroles was also realized by the reaction of aziridines and phenylacetylene in the presence of NaH followed by the treatment with I2 and AgOAc.
