769944-39-0

Basic information

• Product Name: 2-(4-CHLOROPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
• Synonyms: 2-(4-CHLOROPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;1-Boc-2-(4-chlorophenyl)piperazine;tert-Butyl 2-(4-chlorophenyl)piperazine-1-carboxylate
• CAS NO: 769944-39-0
• Molecular Formula: C₁₅H₂₁ClN₂O₂
• Molecular Weight: 296.79
• Mol File: 769944-39-0.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 401.2°C at 760 mmHg
• Flash Point: 196.4°C
• Appearance: /
• Density: 1.155g/cm³
• Vapor Pressure: 1.2E-06mmHg at 25°C
• Refractive Index: 1.531
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-(4-CHLOROPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-CHLOROPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(769944-39-0)
• EPA Substance Registry System: 2-(4-CHLOROPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(769944-39-0)

Safety Data

• Hazardous Substances Data: 769944-39-0(Hazardous Substances Data)

Usage

General Description

2-(4-Chlorophenyl)piperazine-1-carboxylic acid tert-butyl ester is a chemical compound that is a piperazine derivative. It consists of a piperazine ring substituted with a tert-butyl ester at the carboxylic acid and a 4-chlorophenyl group at the 2-position. 2-(4-CHLOROPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER has potential pharmacological and biological activities and is often used in the research and development of pharmaceuticals. It has been studied for its potential as an antidepressant, anxiolytic, and antipsychotic agent. Additionally, it has been investigated for its potential use in the treatment of various neurological disorders.

InChI:InChI=1/C15H21ClN2O2/c1-15(2,3)20-14(19)18-9-8-17-10-13(18)11-4-6-12(16)7-5-11/h4-7,13,17H,8-10H2,1-3H3

Upstream product

• 86147-28-6 3-(4-chloro-phenyl)-piperazin-2-one 
• 24091-92-7 methyl 2-bromo-2-(4-chlorophenyl)acetate 
• 52449-43-1 (4-chloro-phenyl)-acetic acid methyl ester 
• 769944-38-9 4-(tert-butoxycarbonyl)-3-(4-chlorophenyl)-piperazin-2-one 

Relevant articles and documents

Discovery of novel 2-(3-phenylpiperazin-1-yl)-pyrimidin-4-ones as glycogen synthase kinase-3β inhibitors

We herein describe the results of further evolution of glycogen synthase kinase (GSK)-3β inhibitors from our promising compounds containing a 2-phenylmorpholine moiety. Transformation of the morpholine moiety into a piperazine moiety resulted in potent GSK-3β inhibitors. SAR studies focused on the phenyl moiety revealed that a 4-fluoro-2-methoxy group afforded potent inhibitory activity toward GSK-3β. Based on docking studies, new hydrogen bonding between the nitrogen atom of the piperazine moiety and the oxygen atom of the main chain of Gln185 has been indicated, which may contribute to increased activity compared with that of the corresponding phenylmorpholine analogues. Effect of the stereochemistry of the phenylpiperazine moiety is also discussed.