769944-39-0

Usage

Uses

Used in Pharmaceutical Research and Development:
2-(4-CHLOROPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER is used as a research compound for its potential pharmacological and biological activities. It is being studied for its potential as an antidepressant, anxiolytic, and antipsychotic agent, as well as for its potential use in the treatment of various neurological disorders.
Used in Antidepressant Applications:
In the pharmaceutical industry, 2-(4-CHLOROPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER is used as a potential antidepressant agent, aiming to address the unmet needs of patients suffering from depression and related mood disorders.
Used in Anxiolytic Applications:
2-(4-CHLOROPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER is also used as a potential anxiolytic agent, intended to help alleviate anxiety and stress-related disorders.
Used in Antipsychotic Applications:
In the field of psychiatry, 2-(4-CHLOROPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER is used as a potential antipsychotic agent, being investigated for its efficacy in managing symptoms of psychotic disorders.
Used in Neurological Disorder Treatment:
2-(4-CHLOROPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER is used in the research for potential treatments of various neurological disorders, exploring its capacity to address conditions that may benefit from its pharmacological properties.

InChI:InChI=1/C15H21ClN2O2/c1-15(2,3)20-14(19)18-9-8-17-10-13(18)11-4-6-12(16)7-5-11/h4-7,13,17H,8-10H2,1-3H3

Upstream product

• 52449-43-1 (4-chloro-phenyl)-acetic acid methyl ester 
• 24091-92-7 methyl 2-bromo-2-(4-chlorophenyl)acetate 
• 86147-28-6 3-(4-chloro-phenyl)-piperazin-2-one 
• 769944-38-9 4-(tert-butoxycarbonyl)-3-(4-chlorophenyl)-piperazin-2-one 

Relevant academic research and scientific papers

Discovery of novel 2-(3-phenylpiperazin-1-yl)-pyrimidin-4-ones as glycogen synthase kinase-3β inhibitors

We herein describe the results of further evolution of glycogen synthase kinase (GSK)-3β inhibitors from our promising compounds containing a 2-phenylmorpholine moiety. Transformation of the morpholine moiety into a piperazine moiety resulted in potent GSK-3β inhibitors. SAR studies focused on the phenyl moiety revealed that a 4-fluoro-2-methoxy group afforded potent inhibitory activity toward GSK-3β. Based on docking studies, new hydrogen bonding between the nitrogen atom of the piperazine moiety and the oxygen atom of the main chain of Gln185 has been indicated, which may contribute to increased activity compared with that of the corresponding phenylmorpholine analogues. Effect of the stereochemistry of the phenylpiperazine moiety is also discussed.

2, 3, 6-TRISUBSTITUTED-4-PYRIMIDONE DERIVATIVES

A pyrimidone derivative having tau protein kinase 1 inhibitory activity which is represented by formula (I) or a salt thereof, or a solvate thereof or a hydrate thereof; useful for prventive and/or therapeutic treatment of diseass such as neurodegenerative diseases (e.g. Alzheimer disease); wherein Q represents CH or nitrogen atom; R represents a C1-C12 alkyl group; the ring of Formula (I): represents piperazine ring or piperidine ring; each X independently represents a C1-C8 alkyl group, an optionally partially hydrogenated C6-C10 aryl ring, an indan ring or the like; m represents an integer of 1 to 3; each Y independently represents a halogen atom, a hydroxy group, a cyano group, a C1-C6 alkyl group or the like; n represents an integer of 0 to 8; when X and Y or two Y groups are attached on the same carbon atom, they may combine to each other to form a C2-C6 alkylene group.