769957-04-2Relevant articles and documents
Novel and potent 17β-hydroxysteroid dehydrogenase type 1 inhibitors
Lawrence, Harshani R.,Vicker, Nigel,Allan, Gillian M.,Smith, Andrew,Mahon, Mary F.,Tutill, Helena J.,Purohit, Atul,Reed, Michael J.,Potter, Barry V. L.
, p. 2759 - 2762 (2005)
Structure-based drug design using the crystal structure of human 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) led to the discovery of novel, selective, and the most potent inhibitors of 17β-HSD1 reported to date. Compounds 1 and 2 contain a side cha