769963-66-8

Upstream product

• 79069-55-9 tert-butyl [(2S,3R)-3-(benzyloxy)-1-oxobutan-2-yl]carbamate 
• 15260-10-3 N-Boc-O-benzyl-L-threonine 
• 879219-19-9 [(1R,2R)-2-Benzyloxy-1-(5-fluoro-2,3-dihydro-indol-1-ylmethyl)-propyl]-carbamic acid tert-butyl ester 
• 79069-63-9 tert-butyl [(2R,3R)-3-(benzyloxy)-1-hydroxybutan-2-yl]carbamate 

Relevant academic research and scientific papers

Arylaminoethyl amides as noncovalent inhibitors of cathepsin S. Part 2: Optimization of P1 and N-aryl

A systematic study of anilines led to the discovery of a metabolically robust fluoroindoline replacement for the alkoxy aniline toxicophore in 1. Investigations of the P1 pocket resulted in the discovery of a wide tolerance of functionality leading to the discovery of 11 as a potent and selective inhibitor of cathepsin S.