769969-24-6

Basic information

• Product Name: (S)-2-(bis-tert-butoxycarbonylmethyl-amino)-3-(4-nitrophenyl)propionic acid methyl ester
• Synonyms: (S)-2-(bis-tert-butoxycarbonylmethyl-amino)-3-(4-nitrophenyl)propionic acid methyl ester
• CAS NO: 769969-24-6
• Molecular Weight: 452.505
• Mol File: 769969-24-6.mol

Chemical Properties

• CAS DataBase Reference: (S)-2-(bis-tert-butoxycarbonylmethyl-amino)-3-(4-nitrophenyl)propionic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-(bis-tert-butoxycarbonylmethyl-amino)-3-(4-nitrophenyl)propionic acid methyl ester(769969-24-6)
• EPA Substance Registry System: (S)-2-(bis-tert-butoxycarbonylmethyl-amino)-3-(4-nitrophenyl)propionic acid methyl ester(769969-24-6)

Safety Data

• Hazardous Substances Data: 769969-24-6(Hazardous Substances Data)

Upstream product

• 5292-43-3 bromoacetic acid tert-butyl ester 
• 81677-60-3 (L)-p-Nitrophenylalanine methyl ester 
• 2577-90-4 methyl (2S)-2-amino-3-phenylpropanoate 

Downstream Products

• 1619224-45-1 2,2',2''-(10-(2-(4-(2-(bis(carboxymethyl)amino)-3-methoxy-3-oxopropyl)phenylamino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid 

Relevant articles and documents

Design and synthesis of calcium responsive magnetic resonance imaging agent: Its relaxation and luminescence studies

Calcium concentration modulation both inside and outside cell is of considerable interest for nervous system function in normal and pathological conditions. MRI has potential for very high spatial resolution at molecular/cellular level. Design, synthesis and evaluation of Gd-DO3A-AME-NPHE, a calcium responsive MRI contrast agent is presented. The probe is comprised of a Gd3+-DO3A core coupled to iminoacetate coordinating groups for calcium induced relaxivity switching. In the absence of Ca2+ ions, inner sphere water binding to the Gd-DO3A-AME-NPHE is restricted with longitudinal relaxivity, r1 = 4.37 mM-1 s-1 at 4.7 T. However, addition of Ca2+ triggers a marked enhancement in r1 = 6.99 mM-1 s-1 at 4.7 T (60% increase). The construct is highly selective for Ca2+ over competitive metal ions at extracellular concentration. The r1 is modulated by changes in the hydration number (0.2 to 1.05), which was confirmed by luminescence emission lifetimes of the analogous Eu3+ complex. T1 phantom images establish the capability of complex of visualizing changes in [Ca2+] by MRI.

CONJUGATES OF 2,4-ETHANO-BRIDGED AND 2,4-PROPANO-BRIDGED 3,6,9-TRIAZA-NONANOIC ACID, 3N,6N,9,9N-TETRAETHANOIC ACID, AND CORRESPONDING PHOSPHORIC ACID METHYLENE DERIVATIVES AND THE SUBSTITUTION PRODUCTS THEREOF WITH BIOMOLECULES, METHODS FOR THE PRODUCTION THEREOF, AND THE USE OF THE SAME FOR PRODU

The invention relates to conjugates of 2,4-ethano-bridged and 2,4-propano-bridged 3,6,9-triaza-nonanoic acid, N,N,N-tetraethanoic acid, and corresponding phosphoric acid ester methylene derivatives of formula (1) - wherein the substituents are defined as cited in patent claim 1 - and the substitution products thereof with biomolecules. The invention also relates to methods for producing said conjugates and to the use of the same as contrasting media in NMR diagnosis and radiodiagnosis, and for radiotherapy.