77004-75-2

Basic information

• Product Name: BOC-D-ASP-OTBU
• Synonyms: BOC-D-ASP-OTBU;BOC-D-ASPARTIC ACID ALPHA-T-BUTYL ESTER;BOC-D-ASPARTIC ACID-OTBU;N-ALPHA-T-BUTOXYCARBONYL-D-ASPARTIC ACID ALPHA-T-BUTYL ESTER;5-BOC-D-Asp-Ot Bu;N-[(1,1-Dimethylethoxy)carbonyl]-D-aspartic acid 1-(tert-butyl) ester;N-Boc-D-aspartic acid 1-(tert-butyl) ester;N-(tert-butoxycarbonyl)-O1-(tert-butyl)-aspartic acid
• CAS NO: 77004-75-2
• Molecular Formula: C₁₃H₂₃NO₆
• Molecular Weight: 289.32
• Mol File: 77004-75-2.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 429 °C at 760 mmHg
• Flash Point: 213.3 °C
• Appearance: /Solid
• Density: 1.139
• Storage Temp.: 2-8°C
• PKA: 4.13±0.19(Predicted)
• CAS DataBase Reference: BOC-D-ASP-OTBU(CAS DataBase Reference)
• NIST Chemistry Reference: BOC-D-ASP-OTBU(77004-75-2)
• EPA Substance Registry System: BOC-D-ASP-OTBU(77004-75-2)

Safety Data

• Hazardous Substances Data: 77004-75-2(Hazardous Substances Data)

Usage

Chemical Properties

White powder

Uses

N-Boc-D-aspartic Acid 1-tert-Butyl Ester is used in the preparation of optically pure fluoroglutamines and their 18F-labeled derivatives as metabolic imaging agents for tumors. It is also used to synthesize 4-methoxy-7-nitroindolinyl-D-aspartate, a photolabile caged compd. for selective activation of glutamate transporters and N-Me-D-aspartate receptors in brain tissue.

Upstream product

• 126181-44-0 2-Amino-succinic acid 1-tert-butyl ester 4-methyl ester 

Downstream Products

• 1399975-42-8 C₄₂H₅₀N₂O₅P₂ 
• 1262523-76-1 (2R,4S)-tert-butyl-2-(tert-butoxycarbonylamino)-4-fluoro-5-oxo-5-(2,4,6-trimethoxybenzylamino)pentanoate 
• 1262523-98-7 C₂₄H₃₇⁽¹⁸⁾FN₂O₈ 
• 1262523-85-2 (2R,4S)-tert-butyl-2-(tert-butoxycarbonylamino)-5-oxo-4-(tosyloxy)-5-(2,4,6-trimethoxybenzylamino)pentanoate 
• 1262523-83-0 (2R,4R)-tert-butyl-2-(tert-butoxycarbonylamino)-5-oxo-4-(tosyloxy)-5-(2,4,6-trimethoxybenzylamino)pentanoate 
• 1262523-81-8 C₂₄H₃₈N₂O₉ 
• 1262523-79-4 C₂₄H₃₈N₂O₉ 
• 1262523-90-9 C₂₆H₃₉ClN₂O₁₀ 
• 1262523-72-7 (2R,4R)-tert-butyl-2-(tert-butoxycarbonylamino)-4-fluoro-5-oxo-5-(2,4,6-trimethoxybenzylamino)pentanoate 
• 1154035-28-5 C₂₄H₃₅N₅O₉S 
• 110269-45-9 di-tert-butyl N-(tert-butoxycarbonyl)nocardicin A 
• 123004-77-3 (R)-4-[4-((R)-Amino-{(S)-1-[(R)-tert-butoxycarbonyl-(4-hydroxy-phenyl)-methyl]-2-oxo-azetidin-3-ylcarbamoyl}-methyl)-phenoxy]-2-tert-butoxycarbonylamino-butyric acid tert-butyl ester; hydrochloride 
• 123004-76-2 (R)-4-[4-((R)-Benzyloxycarbonylamino-{(S)-1-[(R)-tert-butoxycarbonyl-(4-hydroxy-phenyl)-methyl]-2-oxo-azetidin-3-ylcarbamoyl}-methyl)-phenoxy]-2-tert-butoxycarbonylamino-butyric acid tert-butyl ester 
• 123004-80-8 (R)-2-tert-Butoxycarbonylamino-4-[4-((R)-tert-butoxycarbonylamino-{(S)-1-[(R)-tert-butoxycarbonyl-(4-hydroxy-phenyl)-methyl]-2-oxo-azetidin-3-ylcarbamoyl}-methyl)-phenoxy]-butyric acid tert-butyl ester 

Relevant articles and documents

Synthesis of meta-Carboranyl-(S)-homocysteine Sulfoxide

New (S)-homocysteine derivatives containing a meta-carborane fragment were synthesized. m-Carboranyl-(S)-homocysteine sulfoxide was obtained as a mixture of diastereoisomers. The reduction of the side-chain carboxy group of N-tert-butoxycarbonyl-(S)-aspartic acid α-tert-butyl ester with sodium tetrahydridoborate was not accompanied by racemization.