77006-27-0Relevant academic research and scientific papers
Synthesis of tritiated (RS)-2-amino-2-(3-hydroxy-5-methylisoxazol-4-yl)acetic acid (AMAA), a potent and selective NMDA agonist
Johansen, Tommy N.,Balasubramanian, Venkataraman,Madsen, Ulf,Ferkany, John W.,Krogsgaard-Larsen, Povl
, p. 915 - 922 (2007/10/03)
(RS)-2-Amino-2-(3-hydroxy-5-methylisoxazol-4-yl)acetic acid (AMAA) is a potent and selective agonist at the NMDA subgroup of excitatory amino acid receptors. To probe its interaction with these receptors we have developed a synthesis of [3H]AMAA. Bromination of a protected form of AMAA with NBS followed by hydrogenolysis with tritium gas in the presence of Pd/C and subsequent deprotection gave [3H]AMAA with a specific activity of 25 Ci/mmol. Attempts to develop a receptor binding assay based on rat brain homogenates and using [3H]AMAA as radioligand for the NMDA receptors have not been successful.
N-methyl-D-aspartic acid receptor agonists: Resolution, absolute stereochemistry, and pharmacology of the enantiomers of 2-amino-2-(3-hydroxy-5-methyl-4-isoxazolyl)acetic acid
Madsen, Ulf,Frydenvang, Karla,Ebert, Bjarke,Johansen, Tommy N.,Brehm, Lotte,Krogsgaard-Larsen, Povl
, p. 183 - 190 (2007/10/03)
(R,S)-2-Amino-2-(3-hydroxy-5-methyl-4-isoxazolyl)acetic acid [(R,S)-AMAA, 4] is a potent and selective agonist at the N-methyl-D-aspartic acid (NMDA) subtype of excitatory amino acid receptors. Using the Ugi "four-component condensation" method, the two d
