77022-74-3Relevant academic research and scientific papers
v-Triazolopyrimidines (8-Azapurines). Part 24. The 3-Alkyl Derivatives
Albert, Adrion
, p. 2344 - 2351 (2007/10/02)
4-Methylamino-1,2,3-triazole-5-carboxamide (2e) and its 3-benzyl derivative (2b) were cyclized with hydrochloric acid and triethyl orthoformate to give 3-methyl-8-azapurin-6(1H)-one (1c) and its 9-benzyl derivative (1b).The reaction mechanism is discussed
METHYLATION OF 7-AMINO-vic-TRIAZOLOPYRIMIDINE (8-AZAADENINE) AND ITS N-METHYL DERIVATIVES
Kolesova, M. B.,Smirnova, N. V.
, p. 1879 - 1883 (2007/10/02)
The methylation of 8-azaadenine and its N-methyl derivatives by dimethyl sulfate in an aqueous alkaline medium leads to the N3- and N9-methyl isomers.Further methylation with methyl iodide or methyl benzenesulfonate goes at position 7 or 1 respectively with the formation of iodides or benzenesulfonates.During the thermal decomposition of 3,7- and 1,9-dimethyl-8-azaadeninium iodides transmethylation occurs, and 6-methylamino-9-methyl-8-azapurine is formed.During protonation the latter gives two isomeric salts.Methylation with methyl iodide leads to the formation of two isomeric iodides 1- and 7-methyl-6-methylamino-9-methyl-8-azapurinium iodides.
