770251-13-3

Upstream product

• 770251-05-3 (1-acetyl-5-methyl-7-nitroindolin-4-yloxy)acetic acid 
• 770250-71-0 5-methylindolin-4-ol 
• 19499-82-2 5-(N,N-dimethylaminomethyl)indol-4-ol 
• 770250-89-0 tert-butyl (1-acetyl-5-methylindolin-4-yloxy)acetate 
• 770250-60-7 4-acetoxy-1-acetyl-5-methylindoline 
• 770250-79-8 1-acetyl-5-methylindolin-4-ol 
• 770251-21-3 phosphoric acid 2-[4-(4-{2-[2-(1-acetyl-5-methyl-7-nitro-2,3-dihydro-1H-indol-4-yloxy)-acetylamino]-ethoxy}-benzoyl)-phenoxy]-ethyl ester di-tert-butyl ester 
• 737816-44-3 phosphoric acid 2-{4-[4-(2-amino-ethoxy)-benzoyl]-phenoxy}-ethyl ester di-tert-butyl ester 
• 770250-98-1 tert-butyl (1-acetyl-5-methyl-7-nitroindolin-4-yloxy)acetate 
• 19499-83-3 5-methylindol-4-ol 

Relevant academic research and scientific papers

Optimised synthesis and photochemistry of antenna-sensitised 1-acyl-7-nitroindolines

Benzophenone antenna-sensitised 1-acyl-7-nitroindolines show a significantly enhanced extent of photochemical cleavage in aqueous solution over their non-sensitised analogues and release the carboxylate derived from their 1-acyl group. The present work in

7-NITROINDOLINE DERIVATIVES AND THEIR USES

7-nitroindoline compounds are disclosed that comprise a triplet sensitising group such as substituted or unsubstituted benzophenone group and can be used to cage effector species. In particular, the inclusion of a triplet sensitising group linked to the 4 or 5 position of a 7-nitroindoline derivative provides compounds which can be photolysed to release the effector species with unexpectedly enhanced photolysis efficiency. The triplet sensitising group may be linked directly to the 7-nitroindoline or via a spacer group. In some examples, the triplet sensitising group and/or the spacer group can be selected to enhance other properties of the caged compound such as its solubility, spectroscopic properties or stability (e.g. stability of the linkage between the nitroindoline moiety and the triplet sensitiser). This can help to improve the performance of the caged compound, especially in aqueous environments containing dissolved oxygen.