77038-45-0Relevant academic research and scientific papers
Electrochemical Ammonium Cation-Assisted Hydropyridylation of Ketone-Activated Alkenes: Experimental and Computational Mechanistic Studies
Li, Bingwen,Ma, Jing,Tian, Laijin,Wen, Jiangwei,Yan, Kelu,Yang, Jianjing
supporting information, (2022/01/08)
This work describes an electrochemical ammonium cation enabled hydropyridylation of ketone-activated alkenes under metal- and exogenous reductant free conditions giving access to β-pyridyl ketones, through dual proton-coupled electron transfer and radical cross-coupling. It features a broad substrate scope and allows a gram-scale synthesis. Ammonium chloride plays various roles in this transformation such as the hydrogen donor, the protonation reagent, and electrolyte. In particular, various experiments and density functional theory (DFT) calculation results show the mechanism of dual proton-coupled electron transfer followed by radical cross-coupling is the preferred pathway. (Figure presented.).
3-Methylene flavanones and 3-methylene chromanones
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, (2008/06/13)
Compounds which are 3-methylene flavanones and 3-methylene chromanones having activity against microorganisms are disclosed. The compounds are represented by the general structural formula: STR1 wherein: R1 is a member selected from the group consisting of hydrogen, Br, CH3 and OCH3 ; R2 is selected from the group consisting of hydrogen and STR2 wherein R4 is a member selected from the group consisting of hydrogen, Br, Cl, CH3, OCH3, NO2, N(CH3)3 and CN; R5 is selected from the group consisting of hydrogen and Cl, with the proviso that when R5 is Cl, R4 is hydrogen or Cl; and R3 is selected from the group consisting of hydrogen, phenyl, 2-thienyl, 4-pyridyl and naphthyl, with the proviso that when R3 is naphthyl, R1 and R2 are hydrogen.
