77039-78-2

Basic information

• Product Name: 2-Chromanecarbonylchloride
• Synonyms: 2H-1-Benzopyran-2-carbonyl chloride, 3,4-dihydro- (9CI);Chromane-2-carbonyl chloride
• CAS NO: 77039-78-2
• Molecular Formula: C₁₀H₉ClO₂
• Molecular Weight: 196.63026
• Product Categories: ACIDHALIDE
• Mol File: 77039-78-2.mol

Chemical Properties

• Boiling Point: 292.4°C at 760 mmHg
• Flash Point: 108.9°C
• Appearance: /
• Density: 1.281g/cm³
• Vapor Pressure: 0.00184mmHg at 25°C
• Refractive Index: 1.557
• CAS DataBase Reference: 2-Chromanecarbonylchloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chromanecarbonylchloride(77039-78-2)
• EPA Substance Registry System: 2-Chromanecarbonylchloride(77039-78-2)

Safety Data

• Hazardous Substances Data: 77039-78-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-Chromanecarbonylchloride is used as a reagent in organic synthesis for the production of pharmaceuticals. Its ability to undergo nucleophilic acyl substitution reactions makes it a valuable tool in the development of new molecules and compounds for medicinal applications.
Used in Agrochemical Industry:
In the agrochemical industry, 2-Chromanecarbonylchloride is utilized as a reagent in the synthesis of various agrochemicals. Its reactivity and versatility in organic synthesis contribute to the development of new compounds for agricultural and pest control purposes.
Used in Fine Chemicals Production:
2-Chromanecarbonylchloride is also used in the production of other fine chemicals. Its role as a building block in the synthesis of heterocyclic compounds and organic intermediates highlights its importance in creating specialty chemicals for various applications.

InChI:InChI=1/C10H9ClO2/c11-10(12)9-6-5-7-3-1-2-4-8(7)13-9/h1-4,9H,5-6H2

Upstream product

• 4940-39-0 acide chromone carboxylique-2 
• 51939-71-0 chroman-2-carboxylic acid 

Downstream Products

• 81816-78-6 Chroman-2-yl-(4-phenyl-piperazin-1-yl)-methanone 
• 345934-98-7 Chroman-2-carboxylic acid [2-(4-methoxy-phenyl)-ethyl]-amide 
• 3990-59-8 2-(aminomethyl)chromane 
• 81816-83-3 1-Chroman-2-ylmethyl-4-o-tolyl-piperazine 
• 81816-82-2 N¹-(2'-aminomethylchromanyl)-N⁴-phenylpiperazine 
• 99290-94-5 1-Chroman-2-ylmethyl-piperidine 
• 81816-79-7 Chroman-2-yl-(4-o-tolyl-piperazin-1-yl)-methanone 
• 3990-58-7 chroman-2-ylcarboxamide 

Relevant articles and documents

ANTAGONISTS OF THE TRPV1 RECEPTOR AND USES THEREOF

The present application is directed to compounds that are TRPV1 antagonists and have formula (I) wherein variables Ar1, L1, R1, R2, R3, R4, R5, Y1, Y2, and Y3, are as defined in the description, which are useful for treating disorders caused by or exacerbated by vanilloid receptor activity.

NOVEL SULFONAMIDE SUBSTITUTED CHROMAN DERIVATIVES USEFUL AS BETA-3 ADRENORECEPTOR AGONISTS

This invention relates to novel sulfonamide substituted chroman derivatives which are useful in the treatment of beta-3 receptor mediated conditions.

SUBSTITUTED AMINOMETHYLTETRALINS AND THEIR HETEROCYCLIC ANALOGUES

For binding 5-HT 1 receptors and thereby treating central nervous system disorders, novel substituted aminomethyltetralins and their heterocyclic analogues of the formula STR1 in which Z--denotes a group of the formula STR2 R 1, E and F can be hydrogen or other radicals, or salts thereof.

Benzopyran fungicidal compositions and use

The invention provides fungicidal compositions comprising as an active ingredient a compound having the general formula (I): STR1 or a stereoisomer thereof, wherein X is a methylene group and Y is an oxygen atom, or X is an oxygen atom and Y is a methylen

Pharmacomodulation d'adrenolytiques α en serie benzopyrannique

Pharmacomodulation of α-adrenergic blocking agents by a series of benzopyrans.The N-methylpiperidine fragment was associated with four oxygenated heterocycles of the benzopyran ring system.Two different synthesis pathways were used in each case.Twenty intermediate derivatives and four aminomethylated derivatives whose structures were established by spectroscopic data are described.The pharmacological investigation demonstrates the interest of these compounds on the α-adrenergic receptors in light of their activities and selectivities. α1-adrenergic blocking agents / α2-adrenergic blocking agents / piperidinomethyl chromone, chromene and chromane

α-Adrenoreceptor Reagents. 2. Effects of Modification of the 1,4-Benzodioxan Ring System on α-Adrenoreceptor Activity

Modification of the 1,4-benzodioxan ring present in RX 781094 (1) has not previously been considered.This paper describes a number of analogues of this ring system, including compounds in which one of the oxygen atoms has been replaced by a methylene group and also those in which the ring size has been changed to give, for example, furan and thiophene derivatives.The dihydroxybenzofuranylimidazoline compound 7 is the only analogue possesing presynaptic antagonist potency and selectivity comparable to that of 1.In view of this result, a number of derivatives was prepared to determine the structure-activity relationships within this series.Many derivatives, as well as the parent compound 7, were found to possess presynaptic α2-adrenoreceptor antagonist and postsynaptic α1-adrenoreceptor partial agonist properties.Two of the selective presynaptic antagonists,13 and 14, possess greater potency and selectivity than that possessed by 1.The 5-chloro derivative 25 is twice as potent as 1 after oral administration but only about half as potent when given intravenously.

Phenoxyalkylamines in Semi-rigid Conformation: Synthesis & Pharmacological Activity of N1-(4'-Chromanyl)-N4-arylpiperazines & N1-(2'-Chromanylmethyl)-N4-arylpiperazines

Synthesis and pharmacological activity of N1-(4'-chromanyl)-N4-arylpiperazines and N1-(chromanylmethyl)-N4-arylpiperazines, cyclic congeners of N1-aryloxyalkyl-N4-arylpiperazines, are reported.None of the compounds of this series shows any significant pharmacological activity.