Welcome to LookChem.com Sign In|Join Free
  • or
(1R,2S)-1-(3-Bromo-4-methoxy-phenyl)-cyclopropane-1,2-dicarboxylic acid dimethyl ester is a complex organic compound with the molecular formula C13H15BrO6. It is a chiral molecule, meaning it has a non-superimposable mirror image, and it is characterized by its specific stereochemistry, with the R configuration at the first carbon and the S configuration at the second carbon. (1R,2S)-1-(3-Bromo-4-methoxy-phenyl)-cyclopropane-1,2-dicarboxylic acid dimethyl ester features a cyclopropane ring, which is a three-carbon ring, and is substituted with a 3-bromo-4-methoxy-phenyl group. The molecule also contains two carboxylic acid groups that are esterified with methanol, resulting in dimethyl esters. This specific structure gives the compound unique chemical properties and potential applications in various fields, such as pharmaceuticals or chemical research, where its stereochemistry and functional groups may be of interest.

77053-76-0

Post Buying Request

77053-76-0 Suppliers

Recommended suppliers

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

77053-76-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 77053-76-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,7,0,5 and 3 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 77053-76:
(7*7)+(6*7)+(5*0)+(4*5)+(3*3)+(2*7)+(1*6)=140
140 % 10 = 0
So 77053-76-0 is a valid CAS Registry Number.

77053-76-0Relevant academic research and scientific papers

1-Aryl-3-azabicyclohexanes, a New Series of Nonnarcotic Analgesic Agents

Epstein, Joseph W.,Brabander, Herbert J.,Fanshawe, William J.,Hofmann, Corris M.,McKenzie, Thomas C.,et al.

, p. 481 - 490 (2007/10/02)

A series of 1-aryl-3-azabicyclohexanes was synthesized by hydride reduction of 1-arylcyclopropanedicarboximides.Hydroxyphenyl analogues 20, 22, and 24 were prepared by EtSNa-DMF ether cleavage of the corresponding methoxyphenyl analogues 2m, 2n, and 23, respectively, with the secondary amines 20 and 22 going through the N-formyl intermediates 19 and 21.The p-ethoxy analogue 26 was obtained by O-ethylation of 19, followed by base hydrolysis of the amide 25.The greatest analgesic potency in mouse writhing and rat paw-pain assays was observed for para-substituted compounds.Bicifadine, 1-(4-methylphenyl)-3-azabicyclohexane (2b), was the most potent member of the series and is presently undergoing clinical trials in man.Analgesic activity of 2b is limited to the (+) enantiomer 2v, which has the 1R,5S absolute configuration as determined by single-crystal X-ray analysis.The N-methyl analogue (27d) of 2b showed significant analgesic potency, whereas the N-allyl (27a), N-(cyclopropylmethyl) (27b), and N-(n-hexyl) (27c) analogues were inactive.Bicifadine (2b) showed a nonnarcotic profile different from analogous azabicycloalkane and 3-phenylpyrrolidine analgesics.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1 Customer Service

What can I do for you?
Get Best Price

Get Best Price for 77053-76-0