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(1R,2S)-1-(4-Ethyl-phenyl)-cyclopropane-1,2-dicarboxylic acid is a complex organic compound characterized by its unique molecular structure. It features a cyclopropane ring, which is a three-carbon ring, fused to a benzene ring with an ethyl group attached to the para position. The molecule also contains two carboxylic acid groups, one at each end of the cyclopropane ring, which confer acidic properties. This chiral compound has a specific arrangement of atoms in space, with the R configuration at the first carbon and the S configuration at the second carbon of the cyclopropane ring. The presence of the chiral center and the substituents on the benzene ring contribute to its potential applications in the synthesis of pharmaceuticals and other specialty chemicals, where stereochemistry plays a crucial role in biological activity.

77053-83-9

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77053-83-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 77053-83-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,7,0,5 and 3 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 77053-83:
(7*7)+(6*7)+(5*0)+(4*5)+(3*3)+(2*8)+(1*3)=139
139 % 10 = 9
So 77053-83-9 is a valid CAS Registry Number.

77053-83-9Relevant academic research and scientific papers

1-Aryl-3-azabicyclohexanes, a New Series of Nonnarcotic Analgesic Agents

Epstein, Joseph W.,Brabander, Herbert J.,Fanshawe, William J.,Hofmann, Corris M.,McKenzie, Thomas C.,et al.

, p. 481 - 490 (2007/10/02)

A series of 1-aryl-3-azabicyclohexanes was synthesized by hydride reduction of 1-arylcyclopropanedicarboximides.Hydroxyphenyl analogues 20, 22, and 24 were prepared by EtSNa-DMF ether cleavage of the corresponding methoxyphenyl analogues 2m, 2n, and 23, respectively, with the secondary amines 20 and 22 going through the N-formyl intermediates 19 and 21.The p-ethoxy analogue 26 was obtained by O-ethylation of 19, followed by base hydrolysis of the amide 25.The greatest analgesic potency in mouse writhing and rat paw-pain assays was observed for para-substituted compounds.Bicifadine, 1-(4-methylphenyl)-3-azabicyclohexane (2b), was the most potent member of the series and is presently undergoing clinical trials in man.Analgesic activity of 2b is limited to the (+) enantiomer 2v, which has the 1R,5S absolute configuration as determined by single-crystal X-ray analysis.The N-methyl analogue (27d) of 2b showed significant analgesic potency, whereas the N-allyl (27a), N-(cyclopropylmethyl) (27b), and N-(n-hexyl) (27c) analogues were inactive.Bicifadine (2b) showed a nonnarcotic profile different from analogous azabicycloalkane and 3-phenylpyrrolidine analgesics.

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