77063-12-8Relevant academic research and scientific papers
Thermoresponsive chlorambucil derivatives for tumour targeting
Clavel, Catherine M.,Zava, Olivier,Schmitt, Frederic,Halamoda Kenzaoui, Blanka,Nazarov, Alexey A.,Juillerat-Jeanneret, Lucienne,Dyson, Paul J.
supporting information; experimental part, p. 7124 - 7127 (2011/09/21)
Putting the heat on: Drugs that are essentially inactive at 37°C and are active under mild hyperthermia can be synthesized by modification of chlorambucil with thermoresponsive groups (see picture; C gray, Cl green, F yellow, H white, N blue, O red). This
Synthesis and antitumor activity of 4-[p-[bis(2-chloroethyl)amino]phenyl]butyrates
Roehrig,Billman,Marcec,Fritz,Shea
, p. 1232 - 1234 (2007/10/02)
Ten 4-[p-[bis(2-chloroethyl)amino]phenyl]butyrates were synthesized and evaluated for antitumor activity. The 2-phenoxyethyl ester exhibited activity against P-388 lymphocytic leukemia, and the n-butyl and n-pentyl esters exhibited activity against L-1210 lymphoid leukemia in initial screening tests.
