77063-35-5

Upstream product

• 852919-31-4 (Z)-1-chloro-4-phenylbut-1-en-1-yl acetate 
• 98-86-2 acetophenone 
• 218601-55-9 3-phenylpropyl N,N-diisopropylcarbamate 
• 122-97-4 3-Phenyl-1-propanol 
• 1445-91-6 (S)-1-phenylethanol 
• 133038-72-9 (R)-N,N-diisopropyl O-(1-phenyl)ethylcarbamate 
• 821784-98-9 N,N-diisopropyl O-[(S)-3-phenyl-1-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)]prop-1-yl carbamate 
• 133038-74-1 (S)-(-)-1-phenylethyl N,N-diisopropylcarbamate 
• 67653-13-8 2-((E)-5-Phenyl-pent-2-ene-2-sulfinyl)-pyridine 
• 67653-03-6 2-((E)-4-Phenyl-but-1-ene-1-sulfinyl)-pyridine 
• 77063-30-0 2-((E)-1-Methyl-4-phenyl-but-1-enylsulfanyl)-pyridine 

Relevant academic research and scientific papers

Electrochemical Hydrogenation with Gaseous Ammonia

As a carbon-free and sustainable fuel, ammonia serves as high-energy-density hydrogen-storage material. It is important to develop new reactions able to utilize ammonia as a hydrogen source directly. Herein, we report an electrochemical hydrogenation of alkenes, alkynes, and ketones using ammonia as the hydrogen source and carbon electrodes. A variety of heterocycles and functional groups, including for example sulfide, benzyl, benzyl carbamate, and allyl carbamate were well tolerated. Fast stepwise electron transfer and proton transfer processes were proposed to account for the transformation.

Method for synthesizing succinic acid compounds

The invention provides a method for synthesizing succinic acid compounds. The method specifically comprises the following steps: adding a substrate, a photocatalyst and an alkali into a reaction tube,adding a reducing agent and a solvent under the atmosphere of CO2, conducting reacting under the irradiation of visible light, carrying out quenching treatment after the raw materials react completely, and then conducting separating and purifying to obtain a dicarboxylated product of olefin, namely a succinic acid compound. The photocatalyst is 4CzIPN or Ir[(ppy)2(dtbppy)]PF6 and the like, and the reaction substrate comprises 1,1-diaryl ethylene, a monoaryl substituted olefin compound, an acrylate compound and allene. According to the scheme provided by the invention, the reaction conditionsare mild, the applicability of the reaction substrate is wide, and the yield is basically not influenced under the condition that the reaction substrate is amplified to the gram scale; and meanwhile,the invention overcomes the defects of high toxicity of reagents and harsh reaction conditions in the prior art, and has a good industrial application prospect.

Stereospecific Synthesis of Alkenes by Eliminative Cross-Coupling of Enantioenriched sp3-Hybridized Carbenoids

1-Aryl-1,2-dialkylethenes were generated by a sequence of electrophilic substitution, 1,2-metalate rearrangement, and β-elimination initiated by the addition of enantioenriched α-(carbamoyloxy)alkylboronates to enantioenriched lithiated carbamates. The carbenoid stereochemical pairing [i.e., “like”=(S)+(S) or “unlike”=(S)+(R)] and the elimination mechanism (syn or anti), not substituent effects, determined the configuration of the trisubstituted alkene target. For example, (Z)-2,5-diphenyl-2-pentene was produced in 70 % yield with E/Z=5:95 by a like combination of Li and B carbenoids and syn (thermal) elimination whereas the E isomer was obtained in the same yield with E/Z>98:2 by an otherwise identical process involving an unlike stereochemical pairing. The concept elaborated overcomes an intrinsic limitation of traditional strategies for direct connective alkene synthesis, which cannot realize meaningful stereochemical bias unless the alkene substituents are strongly differentiated.

α-haloenol acetates: Versatile reactants for oxetan-2-one, azetidin-2-one and isoxazolidin-5-one synthesis

New ketene equivalents, namely α-haloenol acetates, are investigated as both nucleophilic and electrophilic reactants in a tandem aldol-lactonization reaction. Diethylaluminum ethoxide proves to be an efficient promoter for the aldol reaction with a wide

HIGHLY STEREOSELECTIVE SYNTHESIS OF TRISUBSTITUTED OLEFINS FROM ALKENYL ARYL SULFOXIDES

Alkenyl aryl sulfoxides could be alkylated stereoselectively via their lithium salts to afford α-alkylated (E)-alkenyl sulfoxides.Reduction of the sulfoxides to the corresponding sulfides followed by nickel-phosphine complexes catalyzed coupling reaction