77064-12-1Relevant academic research and scientific papers
ISOLATION AND CHARACTERIZATION OF NATURAL PRODUCTS FROM PLANT TISSUE CULTURES OF MAYTENUS BUCHANANII
Kutney, James P.,Beale, Michael H.,Salisbury, Phillip J.,Stuart, Kenneth L.,Worth, Brian R.,et al.
, p. 653 - 658 (1981)
Key Word Index - Maytenus buchananii; Celastraceae; tissu culture; polpunonic acid; sitosterol; quinomethides; tingenone; 22β-hydroxytingenone. Explants of Maytenus buchananii were induced to form a callus and subsequently to form suspension cultures on a wide variety of media.Culture extracts showed cytotoxic activity, but examination by TLC did not indicate the presence of maytansine.Isolation of natural products from a large scale suspension culture led to the identification of polpunonic acid, sitosterol and the cytotoxic triterpene quinone-methides, tingenone and 22β-hydroxytingenone.Possible biosynthetic relationships of these and other triterpene quinone-methides are discussed.
