Phytochemistry p. 653 - 658 (1981)
Update date:2022-09-26
Topics:
Kutney, James P.
Beale, Michael H.
Salisbury, Phillip J.
Stuart, Kenneth L.
Worth, Brian R.
et al.
Key Word Index - Maytenus buchananii; Celastraceae; tissu culture; polpunonic acid; sitosterol; quinomethides; tingenone; 22β-hydroxytingenone. Explants of Maytenus buchananii were induced to form a callus and subsequently to form suspension cultures on a wide variety of media.Culture extracts showed cytotoxic activity, but examination by TLC did not indicate the presence of maytansine.Isolation of natural products from a large scale suspension culture led to the identification of polpunonic acid, sitosterol and the cytotoxic triterpene quinone-methides, tingenone and 22β-hydroxytingenone.Possible biosynthetic relationships of these and other triterpene quinone-methides are discussed.
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