770696-39-4Relevant articles and documents
New chemical agents based on adamantane-monoterpene conjugates against orthopoxvirus infections
Agafonov, Alexander P.,Bormotov, Nikolay I.,Korchagina, Dina V.,Maksyutov, Rinat A.,Mozhaytsev, Evgenii S.,Salakhutdinov, Nariman F.,Serova, Olga A.,Shishkina, Larisa N.,Suslov, Evgenii V.,Volcho, Konstantin P.,Yarovaya, Olga I.
, p. 1185 - 1195 (2020/11/03)
Currently, the spectrum of agents against orthopoxviruses, in particular smallpox, is very narrow. Despite the fact that smallpox is well controlled, there is, for many reasons, a real threat of epidemics associated with this or a similar virus. In order to search for new low molecular weight orthopoxvirus inhibitors, a series of amides combining adamantane and monoterpene moieties were synthesized using 1- and 2-adamantanecarboxylic acids as well as myrtenic, citronellic and camphorsulfonic acids as acid components. The produced compounds exhibited high activity against the vaccinia virus (an enveloped virus belonging to the poxvirus family), which was combined with low cytotoxicity. Some compounds had a selectivity index higher than that of the reference drug cidofovir; the highest SI = 1123 was exhibited by 1-adamantanecarboxylic acid amide containing the (-)-10-amino-2-pinene moiety. The produced compounds demonstrated inhibitory activity against other orthopoxviruses: cowpox virus (SI = 30-406) and ectromelia virus (mousepox virus, SI = 39-707). This journal is
Synthesis of 2-exo- and 2-endo-Mecamylamine Analogues. Structure-Activity Relationships for Nicotinic Antagonism in the Central Nervous System
Suchocki, John A.,May, Everette L.,Martin, Thomas J.,George, Clifford,Martin, Billy R.
, p. 1003 - 1010 (2007/10/02)
Nine analogues of mecamylamine (2) which differ in the number and substitution pattern of methyl groups, were prepared.In four of these analogues the amine functionality is in an endo orientation.Enantiomers of 2-endo- and 2-exo-N-methylfenchylamine (25 and 26, respectively) were also prepared.The hydrochloride salts of these compounds were tested for nicotinic antagonism relative to mecamylamine in vivo and none was found to be as potent as mecamylamine, although a broad range of activity was observed.In general, methyl substituents at the C1, C2, and C7 positions of the mecamylamine structure do not appear to be significant for antagonistic activity.Methyl substituents at C3, however, appear to be very important for activity.Three sets of enantiomers of N-methylfenchylamine analogues, 28-30, possessing structural features of mecamylamine and nicotine were also prepared.These compounds were inactive as antagonists.Only a small degree of stereoselectivity was elicited in this series, less than that seen with enantiomers of nicotine.Antagonists with the exo N-methylamine functionality are slightly more active than the endo isomers.The extent to which structural modification might change lipophilicities was estimated through calculated partition coefficients; such changes alone appeared insufficient to explain differences in activities of the analogues.Lastly, a tolerance for a tertiary (dimethyl) amine functionality was demonstrated in addition to the lack of tolerance for bulkier substituents at C3 or on the nitrogen.
