770709-08-5Relevant academic research and scientific papers
Diastereoselective hydrolysis of α,γ-substituted γ-sultones in the asymmetric synthesis of γ-hydroxy sulfonates
Enders, Dieter,Harnying, Wacharee,Raabe, Gerhard
, p. 590 - 594 (2004)
The hydrolysis of enantiopure α,γ-substituted γ-sultones with water under mild conditions leads to α,γ-substituted γ-hydroxy methyl sulfonates in very good yields and excellent diastereo- and enantiomeric excesses (de, ee ≥ 98%). The reaction proceeds via a S N2 mechanism with inversion of configuration at the attacked γ-carbon atom whose absolute configuration was established by X-ray crystallography.
