77076-26-7

Basic information

• Product Name: cyclohexyl L-valinate hydrochloride
• Synonyms: cyclohexyl L-valinate hydrochloride
• CAS NO: 77076-26-7
• Molecular Weight: 235.754
• Mol File: 77076-26-7.mol

Chemical Properties

• CAS DataBase Reference: cyclohexyl L-valinate hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: cyclohexyl L-valinate hydrochloride(77076-26-7)
• EPA Substance Registry System: cyclohexyl L-valinate hydrochloride(77076-26-7)

Safety Data

• Hazardous Substances Data: 77076-26-7(Hazardous Substances Data)

Upstream product

• 72-18-4 L-valine 
• 108-93-0 cyclohexanol 
• 13734-41-3 t-Boc-L-valine 

Downstream Products

• 1177465-43-8 C₁₈H₂₇ClNO₅P 

Relevant articles and documents

Identification of a 4-fluorobenzyl L-valinate amide benzoxaborole (AN11736) as a potential development candidate for the treatment of Animal African Trypanosomiasis (AAT)

Novel L-valinate amide benzoxaboroles and analogues were designed and synthesized for a structure-activity-relationship (SAR) investigation to optimize the growth inhibitory activity against Trypanosoma congolense (T. congolense) and Trypanosoma vivax (T. vivax) parasites. The study identified 4-fluorobenzyl (1-hydroxy-7-methyl-1,3-dihydrobenzo[c][1,2]oxaborole-6-carbonyl)-L-valinate (5, AN11736), which showed IC50 values of 0.15 nM against T. congolense and 1.3 nM against T. vivax, and demonstrated 100% efficacy with a single dose of 10 mg/kg against both T. congolense and T. vivax in mouse models of infection (IP dosing) and in the target animal, cattle, dosed intramuscularly. AN11736 has been advanced to early development studies.

ANTIVIRAL COMPOUNDS

The present disclosure provides compounds for treating a variety of diseases, such as respiratory syncytial virus (RSV), HRV, hMPV, ebola, Zika, West Nile, Dengue, and HCV.