77083-72-8

Upstream product

• 1265801-93-1 3-hydroxy-1-phenyl-2-(2-p-tolylhydrazono)propan-1-one 
• 614-20-0 3-oxo-3-phenylpropionic acid 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 1201-93-0 1-phenyl-3-dimethylaminoprop-2-enone 
• 106-49-0 p-toluidine 

Downstream Products

• 613-90-1 benzoyl cyanide 
• 3085-54-9 N-(4-methylphenyl)formamide 
• 582-78-5 N-(4-methylphenyl)benzamide 
• 106-49-0 p-toluidine 
• 1394240-53-9 2-hydroxy-6-phenyl-5-p-tolylazothionicotinamide 
• 1394240-54-0 2-amino-6-phenyl-5-p-tolylazonicotinic acid ethyl ester 
• 1394240-51-7 2-hydroxy-6-phenyl-5-p-tolylazonicotinic acid ethyl ester 
• 936132-71-7 3-oxo-3-phenyl-2-(p-tolylhydrazono)propanal oxime 
• 936132-75-1 3-oxo-3-phenyl-2-(p-tolylhydrazono)propanal oxime 
• 22744-14-5 (E)-2-oxo-2-phenyl-N′-p-tolylacetohydrazonoyl cyanide 
• 81404-75-3 1-Phenyl-3-[(E)-phenylimino]-2-(p-tolyl-hydrazono)-propan-1-one 

Relevant academic research and scientific papers

Reactions under Pressure: Synthesis of Functionally Substituted Arylhydrazonal Derivatives as Precursors of Novel Pyridazines and Nicotinates

Abstract: Q-tube assisted multicomponent synthesis of novel arylhydrazonals, pyridazines and nicotinates has been explored. The target molecules have been prepared via one pot reaction of arylhydrazonals with activated methylene nitriles in either ethanol

Improved synthesis of 2-arylhydrazono-3-hydroxy-1-propanones and their utility in efficient synthesis of pyridazine derivatives

Reaction of 2-arylhydrazono-1-phenylethanones 2a-c with formaldehyde either in presence of montmorillonite K10 or by simply stirring in methanol and TEA leads to selective synthesis of 2-arylhydrazono-3-hydroxy-1-phenylpropan-1-one derivatives 3a-c in high yield. Heating 1a with N-phenylmaleimide in DPE/DABCO using microwave irradiation for 5 minutes at 200 °C results in a 73% yield of pyrrolo[3, 4-c]pyridazine 8. Compounds 2a-c react with benzylidenemalononitriles 9a or ethyl 2-cyanocinnamate 9b in refluxing ethanol and piperidine or β-chitosan to yield new pyridazine derivatives 10a-f which are converted into pyridazinones 11a-c upon reflux in acetic/hydrochloric acids mixture. ARKAT-USA, Inc.