7709-31-1

Upstream product

• 2010-06-2 2-Amino-4-phenylthiazole 
• 1147550-11-5 ammonium thiocyanate 
• 4921-87-3 N-benzoyl-N'-(4-phenylthiazole-2-yl)thiocarbamide 
• 541-53-7 2,4-Dithiobiuret 
• 70-11-1 α-bromoacetophenone 
• 7709-52-6 (4-phenyl-thiazol-2-yl)-cyanamide 
• 98-86-2 acetophenone 

Downstream Products

• 7709-47-9 2-benzyl-1-(4-phenyl-thiazol-2-yl)-isothiourea 
• 68666-17-1 [4-(3,4-dichloro-phenyl)-thiazol-2-yl]-(4-phenyl-thiazol-2-yl)-amine 
• 52413-89-5 3-(4-phenyl-thiazol-2-yl)-2-thioxo-imidazolidin-4-one 
• 89402-66-4 [4-(4-Chloro-phenyl)-2-(4-phenyl-thiazol-2-ylamino)-thiazol-5-yl]-acetic acid 
• 129329-95-9 2,2'-imino-bis-5,5'-dichloro-4,4'-diphenylthiazole 
• 129329-96-0 (5-Chloro-4-phenyl-thiazol-2-yl)-(5-chloro-4-p-tolyl-thiazol-2-yl)-amine 
• 129329-97-1 [5-Chloro-4-(4-chloro-phenyl)-thiazol-2-yl]-(5-chloro-4-phenyl-thiazol-2-yl)-amine 
• 129329-98-2 [4-(4-Bromo-phenyl)-5-chloro-thiazol-2-yl]-(5-chloro-4-phenyl-thiazol-2-yl)-amine 
• 52414-20-7 5-(4-diethylamino-benzylidene)-3-(4-phenyl-thiazol-2-yl)-2-thioxo-imidazolidin-4-one 
• 52471-11-1 5-(2-nitro-benzylidene)-2-(4-phenyl-thiazol-2-ylamino)-thiazol-4-one 
• 52413-95-3 5-(4-nitro-benzylidene)-2-(4-phenyl-thiazol-2-ylamino)-thiazol-4-one 
• 52414-17-2 5-(2-nitro-benzylidene)-3-(4-phenyl-thiazol-2-yl)-2-thioxo-imidazolidin-4-one 
• 52471-17-7 5-(4-nitro-benzylidene)-3-(4-phenyl-thiazol-2-yl)-2-thioxo-imidazolidin-4-one 
• 52600-07-4 5-bromo-5-[bromo-(2-chloro-phenyl)-methyl]-3-(4-phenyl-thiazol-2-yl)-2-thioxo-imidazolidin-4-one 

Relevant academic research and scientific papers

Synthesis and biological evaluation of substituted thiazolamine, imidazo [2,1-b] thiazol-6(5H)-one, thiazolo [3,2-a] pyrimidin-5-one and thiazolyl thiourea derivatives

Substituted phenyl thiazole-2-amines (TA1-4) refluxed with ethyl acetoacetate using phosphorus oxychloride and polyphosphoric acid as a catalyst yielded thiazolo- pyrimidines (TP1-4) and with chloroacetic acid in ethanol furnished imizado- Thiazolos (IT1-4). Thiazolyl thioreas (TT1-4) were synthesized by the reaction of TA1-4 with ammonium thiocynate in dil hydrochloric acid. The structures of the synthesized compounds have been established on the basis of their spectral data and drug likelines was analyzed using Molinspiration online resource. The in vitro tuberculostatic potential evaluated against H37Rv strain of Mycobacterium tuberculosis by REMA assay has shown moderate activity for compound IT2. Synthesized compounds were screened against Staphylococcus aureus (MTCC 3160), Bacillus subtilis (MTCC 441), Escherichia coli (MTCC 40) and Pseudomonus aeruginosa (MTCC 424) bacteria and have shown significant activity.

Synthesis and biological evaluation of substituted thiazolamines, imidazo [2,1b] thiazol-6-(5h)-ones, thiazolo [3,2-a] pyrimidin-5-ones and thiazolyl thioureas

Substituted phenyl thiazole-2-amines (TA1-4) when refluxed with ethyl acetoacetate using phosphorous oxychloride and poly phosphoric acid as a catalyst yielded thiazolo-pyrimidines (TP1-4) and with chloroacetic acid in ethanol furnished imidazol-thiazoles (IT1-4). Thiazolyl thioureas (TT1-4) were synthesized by the reaction of TA 1-4 with ammonium thiocynate in dilute hydrochloric acid. The structures of the synthesized compounds have been established on the basis of their spectral data and drug likeliness was analyzed using Molinspiration online resource. The in vitro tuberculostatic potential was evaluated against H 37Rv strain of Mycobacterium tuberculosis by REMA assay and showed moderate activity for compound IT3 Synthesized compounds were also screened against Staphylococcus aureus (MTCC 3160), Bacillus subtilis (MTCC 441), Escherichia coli (MTCC 40) and Pseudomonus aeruginosa (MTC 424) bacteria and showed significant activity.

GUANIDINE COMPOUNDS, AND USE THEREOF AS BINDING PARTNERS FOR 5-HT5 RECEPTORS

The invention relates to guanidine compounds of general formula (I), corresponding enantiomeric, diastereomeric, and/or tautomeric forms thereof, and pharmaceutically acceptable salts thereof. The invention further relates to the use of guanidine compounds as binding partners for 5-HT5 receptors in order to treat diseases modulated by 5-HT5 receptor activity, especially treat neurodegenerative and neuropsychiatric disorders and the signs, symptoms, and malfunctions associated therewith.

Synthesis and Antiinflammatory Activity of Some 5-Thiazoleacetic Acids

Four series of 5-thiazoleacetic acids (I, II, III and IV) have been synthesized for evaluation as potential antiinflammatory agents.Compounds of the series I, II and IV have been prepared by the condensation of various β-aroyl-β-bromopropionic acids (VIII