7710-13-6

Upstream product

• 333-20-0 potassium thioacyanate 
• 100-20-9 terephthaloyl chloride 
• 1147550-11-5 ammonium thiocyanate 
• 540-72-7 sodium thiocyanide 

Downstream Products

• 13995-83-0 1,1'-(4,4'-dimethyl-6,6'-dithioxo-1,6,1',6'-tetrahydro-2,2'-p-phenylene-di-pyrimidin-5-yl)-bis-ethanone 
• 1263194-87-1 3,3'-[(1,4-phenylene)bis(carbonyliminocarbonothioylimino)]bis[benzoic acid chloride] 
• 1263194-84-8 3,3'-[(1,4-phenylene)bis(carbonyliminocarbonothioylimino)]bis[benzoic acid] 
• 1616410-47-9 2-[[4-(carboxymethylcarbamothioylcarbamoyl)benzoyl]carbamothioylamino]acetic acid 
• 1616410-49-1 2-[[4-[(2-hydroxy-1-methyl-2-oxo-ethyl)carbamothioylcarbamoyl]benzoyl]carbamothioylamino]propanoic acid 

Relevant academic research and scientific papers

Self-Assembly of Discrete Copper(I)-Halide Complexes with Diacylthioureas

Three diacylthioureas 1,4-C6H4[C(O)NHC(S)NHAr]2 (Ar = 2,6-iPr2C6H3) (L1, 1), 1,3-C6H4[C(O)NHC(S)NHAr]2 (L2, 2), and 1,3-C6H

Assessing the biological potential of new symmetrical ferrocene based bisthiourea analogues

In the present work synthesis and characterization of five new bisferrocenyl bisthiourea analogues (G2M, S2M, G3F, G4F and T2M) is reported. UV–Visible and electrochemical studies were performed in order to have optical (absorption maximum, Molar absorption coefficient and optical band gap) and electrochemical parameters (Oxidation/reduction potentials and nature of the electrochemical process) of the compounds. In vitro various biological studies such as antibacterial, antifungal, anti-oxidant and antidiabetic activities were carried out to have comparative overview of the phermacochemical strength of the newly synthesized compounds. Similarly, theoretical analysis was accomplished utilizing density functional theory calculations. DFT/B3LYP (6-31G d, p) technique was used. With a view to explore the structure activity relationship (SAR) of the compounds theoretical docking analysis (against α-amylase, α-glucosidase) was also performed to have pictorial view and understanding of the actual interactions responsible for the activity. S2M displayed best antibacterial activity. Similarly, Antifungal and antidiabetic activities showed G3F as a best candidate, whereas T2M proved to be the best antioxidant agent.

Synthesis and characterization of halogenated bis(acylthiourea) derivatives and their antibacterial activities

A total of 12 bis(acylthiourea) derivatives with different pharmacophores have been synthesized via nucleophilic substitution reaction of benzene-1,4-dicarbonyl isothiocyanate intermediate with aromatic amine bearing halogens at the ortho, meta and para p

Self-assembly of bis-[1]rotaxanes based on diverse thiourea-bridged mono-functionalized dipillar[5]arenes

The condensation reaction of mono-amido-functionalized pillar[5]arenes with tere- and iso-phthaloyl diisothiocyanates in acetone under ultrasonic irradiation afforded tere- and iso-phthaloylthiourea-bridged dipillar[5]arenes. The similar reaction of mono-

2-Amino-4-aryl thiazole: A promising scaffold identified as a potent 5-LOX inhibitor

Human 5-lipoxygenase (5-LOX) is an important enzyme in the biosynthesis of leukotrienes and is a target for asthma and allergy treatment. Zileuton is the only drug currently marketed that targets this enzyme (IC50 ～ 1 μM). So, the development of novel lead compounds is highly desirable. A series of 2-aryl indole, thiazolopyrazole acid, oxadiazolobenzothiophene, 1,4-disubstituted-1,2,3-triazole, 2-amino-4-aryl thiazole and 4,4′-(1,4-phenylene)bis(1,3-thiazole) derivatives when tested against this enzyme resulted in the identification of a potent compound (1d), p-fluoro substituted 2-amino-4-aryl thiazole, with an IC50 of ～10 μM. Another lead compound identified is (4a), a thiazolopyrazole acid derivative (IC50 ～ 40 μM). All the compounds exhibit poor DPPH radical scavenging activity which suggests that their action occurs not due to the disruption of the redox cycle of iron present in the enzyme (unlike zileuton) but through competitive inhibition, since the Vmax remains constant but the Km increases with an increase in inhibitor concentration. Molecular docking of 1d and 4a to the active site of 5-LOX also supports the experimental data, and suggests that their possible mechanism of action is through competitive inhibition. The current study identifies a promising lead molecule which could be improved further to match the activity of the commercial drug.

Dicapryloyl diisothiocyanate derivative and preparing method and application thereof

The invention provides a dicapryloyl diisothiocyanate derivative and a preparing method and application thereof.The molecular structure of the dicapryloyl diisothiocyanate derivative contains a great number of lipophilic groups such as thioacid amide, thiourea and thioamide ester and carboxyl hydrophilic groups.The preparing method includes the steps that diacyl chloride and thiocyanate are subjected to a substitution reaction to generate the intermediate product dicapryloyl diisothiocyanate, and the intermediate product and an alcohol, amine, mercaptan or phenolic compound are subjected to an addition reaction to generate the dicapryloyl diisothiocyanate derivative.The preparing method is simple, the prepared dicapryloyl diisothiocyanate derivative serving as a non-molybdenum sulfide ore inhibitor applied to flotation separation of sulfuration molybdenum ore and non-molybdenum sulfide ore, the sulfuration molybdenum ore can be effectively separated from copper sulfide ore, galena, sphalerite, iron pyrite bismuth sulphide ore, and the grade of molybdenum concentrate is improved.

One-pot and two-step synthesis of novel carbonylthioureas and dicarbonyldithioureas derivatives

Abstract One-pot, two-step synthesis of several 1-cyclopropanecarbonyl-3-(substituted phenyl)-thioureas and 1-(phenylene-1,4-dione)-3,3′-(substituted phenyl)-dithioureas have been successfully prepared. The structures of the synthesized compounds were con

Bis-Thiourea bearing aryl and amino acids side chains and their antibacterial activities

(Equation present) A series of symmetrical 1,3-bis thiourea 1a-e and 1,4-bis thiourea derivatives 2a-e have been successfully synthesized from the reactions of amines with 3-acetylbenzoyl isothiocyanate and 4-acetylbenzoyl isothiocyanate, respectively. All the synthesized compounds were characterized by FT-IR spectroscopy and 1H and 13C NMR spectroscopy. The compounds were screened for their antibacterial activity by turbidimetric method using gram-negative bacteria (E. coli ATCC 8739) using turbidimetric method. The newly synthesized bis-thiourea derivatives bearing aryl side chains showed good antibacterial activity against E. coli. The effect of the molecular structure of the synthesized compounds on the antibacterial activity is discussed. 2014 Copyright Taylor & Francis Group, LLC.

Synthesis and characterization of novel thermally stable aromatic and semiaromatic polyamides derived from thiourea-based flexible diacid dichlorides

New diacid dichlorides bearing phenyl thiourea groups were prepared by a facile synthetic approach and characterized using spectroscopic and elemental analyses. A series of novel aromatic and semiaromatic polyamides were prepared via a condensation route