77100-17-5

Upstream product

• 2133-40-6 D-proline methyl ester hydrochloride 
• 344-25-2 D-Prolin 
• 43041-12-9 methyl (2R)-pyrrolidine-2-carboxylate 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 77087-63-9 N-(tert-butyloxycarbonyl)-L-phenylalanyl-D-proline methyl ester 

Downstream Products

• 5654-85-3 (3S,8aS)-3-benzyloctahydropyrrolo[1,2-a]pyrazine-1,4-dione 
• 1569904-20-6 C₃₅H₄₄N₆O₆ 
• 82113-25-5 TFA*Ala-Aib-Phe-D-Pro-OSu 
• 82113-06-2 Aib-Phe-D-Pro-Ala-OSu*HCl 
• 82113-04-0 N-hydroxysuccinimide ester of (p-methoxybenzyloxycarbonyl)-α-aminoisobutyryl-L-phenylalanyl-D-prolyl-L-alanine 
• 82113-20-0 Boc-Ala-Aib-Phe-D-Pro-OSu 
• 82113-19-7 Boc-Ala-Aib-Phe-D-Pro-OH 
• 82113-18-6 (tert-butyloxycarbonyl)-L-alanyl-α-aminoisobutyryl-L-phenylalanyl-D-proline methyl ester 
• 82113-02-8 N-(p-methoxybenzyloxycarbonyl)-α-aminoisobutyryl-L-phenylalanyl-D-proline methyl ester 
• 82113-03-9 N-(p-methoxybenzyloxycarbonyl)-α-aminoisobutyryl-L-phenylalanyl-D-proline 
• 71996-70-8 cyclo(α-aminoisobutyryl-L-phenylalanyl-D-prolyl-L-alanyl) 
• 183609-55-4 L-phenylalanyl-D-proline methyl ester 
• 77087-61-7 methyl N-(benzyloxycarbonyl)glycyl-L-phenylalanyl-D-prolinate 

Relevant academic research and scientific papers

Efficient synthesis of 2,5-diketopiperazines using microwave assisted heating

In this study a general, efficient and environmentally benign solution phase synthesis of 2,5-diketopiperazines (DKPs) using microwave assisted heating in water is described. A series of 11 structurally different DKPs have been synthesized from dipeptide methyl esters. A range of common laboratory solvents have been tested as well as different reaction times and temperatures. Both classic thermal and microwave assisted heating have been investigated. Microwave assisted heating for 10 min using water as solvent proved, by far, to be the most efficient method of cyclization giving moderate to excellent yields (63-97%) of DKPs. In contrast to other published procedures, this method seems independent of the amino acid sequence.

Improved Synthesis of chlamydocin: Cyclization Studies of Tetrapeptides Containing Five α-Substituents

A complete search for the optimal conditions for preparing cycling tetrapeptide 2 was carried out.In this study all four possible sequences of the linear tetrapeptide precursors were synthesized and cyclized.The results establish that one linear sequence is especially favorable for synthesizing the peptide ring system in chlamydocin (1).