77101-49-6Relevant academic research and scientific papers
Synthesis and biological evaluation of Zeise’s salt derivatives with acetylsalicylic acid substructure
Weninger, Alexander,Baecker, Daniel,Obermoser, Victoria,Egger, Dorothea,Wurst, Klaus,Gust, Ronald
, (2018)
The development of novel biologically active organometallic compounds bearing an acetylsalicylic acid (ASA) substructure led to the synthesis of analogical Zeise-type salts that accordingly inhibit cyclooxygenase (COX) enzymes. In order to determine the i
In situ synthesis of 2-allyloxy-1-methylpyridinium triflate for the allylation of carboxylic acids
Strayer, Timothy A.,Culy, Caleb C.,Bunner, Matthew H.,Frank, Amie R.,Albiniak, Philip A.
, p. 6807 - 6809 (2016/01/26)
2-Allyloxypyridinium triflate is formed in situ by treating a mixture of 2-allyloxypyridine, a carboxylic acid, and toluene with methyl triflate. Subsequent warming of the reaction mixture in the presence of potassium carbonate leads to efficient formation of allyl esters in good to excellent yields.
Synthesis of NO-NSAID dendritic prodrugs via Passerini reaction:new approach to the design of dendrimer-drug conjugates
Du, Zuyin,Yanhui, Lu,Dai, Xuedong,Zhang-Negrerie, Daisy,Gao, Qingzhi
, p. 181 - 185 (2013/07/05)
We report the synthesis of a novel class of dendritic prodrugs via Passerini reaction in one pot. Such dendrimers feature a simultaneous attachment of a conventional non-steroidal anti-inflammatory drug (NSAID) (such as ibuprofen and aspirin) and a nitric oxide (NO)-releasing moiety (such as an organic nitrate) onto their surface, and are therefore regarded as new drug delivery systems for NO-releasing NSAIDs (NO-NSAIDs).
