77103-01-6

Usage

Uses

Used in Pesticide Industry:
((3-Phenoxyphenyl)methylene)methane-1,1-dicarbonitrile is used as an active ingredient in insecticides and pesticides. It is valued for its insecticidal properties, which stem from its ability to disrupt the nervous system of insects, causing paralysis and death.
Used in Pharmaceutical Industry:
((3-PHENOXYPHENYL)METHYLENE)METHANE-1,1-DICARBONITRILE also serves as a reagent in organic synthesis, playing a crucial role in the production of various pharmaceuticals. Its unique structure allows it to be a versatile building block for the development of new drugs.
Used in Agrochemical Industry:
In addition to its applications in the pharmaceutical sector, ((3-Phenoxyphenyl)methylene)methane-1,1-dicarbonitrile is also utilized in the agrochemical industry for the synthesis of different agrochemical products, contributing to crop protection and enhancement of agricultural yields.

Upstream product

• 87199-16-4 3-Formylphenylboronic acid 
• 108-95-2 phenol 
• 39515-51-0 3-Phenoxybenzaldehyde 
• 109-77-3 malononitrile 

Downstream Products

• 1019063-19-4 2-amino-5,10-dioxo-4-(3-phenoxyphenyl)-5,10-dihydro-4H-benzo[g]chromene-3-carbonitrile 
• 475045-78-4 6-amino-3-methyl-4-(3-phenoxyphenyl)-1-phenyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile 
• 1394052-31-3 6-amino-3-methyl-4-(3-phenoxyphenyl)-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile 

Relevant academic research and scientific papers

Cinnamonitrile adjuvants restore susceptibility to β-lactams against methicillin-resistant staphylococcus aureus

β-Lactams are used routinely to treat Staphylococcus aureus infections. However, the emergence of methicillin-resistant S. aureus (MRSA) renders them clinically precarious. We describe a class of cinnamonitrile adjuvants that restore the activity of oxacillin (a penicillin member of the β-lactams) against MRSA. The lead adjuvants were tested against six important strains of MRSA, one vancomycin-intermediate S. aureus (VISA) strain, and one linezolid-resistant S. aureus strain. Five compounds out of 84 total compounds showed broad potentiation. At 8 μM (E)-3-(5-(3,4-dichlorobenzyl)-2-(trifluoromethoxy)phenyl)-2-(methylsulfonyl)acrylonitrile (26) potentiated oxacillin with a >4000-fold reduction of its MIC (from 256 to 0.06 mg·L-1). This class of adjuvants holds promise for reversal of the resistance phenotype of MRSA.

Synthesis and Biological Evaluation of Furo[3,2-c]pyrazole-5-carbimidates

In the present work, novel pyrazole fused dihydrofurans synthesized via a chronological addition of N-chloro succinimide and base piperidine to pyrano[3,2-c]pyrazole carbonitrile derivatives in methanol medium. Oxidative difunctionalization was done with

A highly efficient protocol for the regio- and stereo-selective synthesis of spiro pyrrolidine and pyrrolizidine derivatives by multicomponent reaction

A series of novel spiro[acenaphthylene-1,2′-pyrrolidine] (4), spiro[acenaphthylene-1,2′-pyrrolizidine] (7), and spiro[indoline-3, 2′-pyrrolidine] derivatives (9) containing cyano group were successfully synthesized via a three-component 1,3-dipolar cycloaddition reaction of acenaphthenequinone or isatin, sarcosine or proline, and Knoevenagel adducts in refluxing aqueous methanol. In this intermolecular three-component combinatorial process it is amazing that three stereogenic centers with one spiro carbon are controlled very well. The structure and relative stereo-chemistry of cycloadducts were carried out by single crystal X-ray diffraction, as well as by the help of 1H, 13C, and HMBC spectroscopy.

Structural simplification of bioactive natural products with multicomponent synthesis. 4. 4H-Pyrano-[2,3-b]naphthoquinones with anticancer activity

4H-Pyrano-[2,3-b]naphthoquinone is a structural motif commonly found in natural products manifesting anticancer activities. As part of a program aimed at structural simplification of bioactive natural products utilizing multicomponent synthetic processes,

Eco-friendly synthesis and biological evaluation of substituted pyrano[2,3-c]pyrazoles

An ecofriendly green approach for synthesis of substituted pyrano[2,3-c]pyrazoles has been developed via a multicomponent one pot approach in aqueous ethanol medium under totally non-catalytic conditions. The synthesized compounds were evaluated for their