77103-91-4Relevant academic research and scientific papers
Analogues of Acifran: Agonists of the high and low affinity niacin receptors, GPR109a and GPR109b
Jung, Jae-Kyu,Johnson, Benjamin R.,Duong, Tracy,Decaire, Marc,Uy, Jane,Gharbaoui, Tawfik,Boatman, P. Douglas,Sage, Carleton R.,Chen, Ruoping,Richman, Jeremy G.,Connolly, Daniel T.,Semple, Graeme
, p. 1445 - 1448 (2007/10/03)
Recently identified GPCRs, GPR109a and GPR109b, the high and low affinity receptors for niacin, may represent good targets for the development of HDL elevating drugs for the treatment of atherosclerosis. Acifran, an agonist of both receptors, has been tested in human subjects, yet until recently very few analogs had been reported. We describe a series of acifran analogs prepared using newly developed synthetic pathways and evaluated as agonists for GPR109a and GPR109b, resulting in identification of compounds with improved activity at these receptors.
Hypolipidemic 4,5-Dihydro-4-oxo-5,5-disubstituted-2-furancarboxylic Acids
Jirkovski, Ivo,Cayen, Mitchell, N.
, p. 1154 - 1156 (2007/10/02)
A series of novel 4,5-dihydro-4-oxo-5,5-disubstituted-2-furancarboxylic acids was synthesized and shown to possess potent hypotriglyceridemic activity in normal rats.In contrast to clofibrate, none of the present compounds altered liver weight at any dose
Hypolipidemic derivatives of 4,5-dihydro-4-oxofuran-2-carboxylic acid
-
, (2008/06/13)
Derivatives of 4,5-dihydro-4-oxofuran-2-carboxylic acid characterized by having two substituents at position 5 and in addition being optionally further substituted at position 3 with a lower alkyl group, as well as esters therefor are disclosed. The foreg
Process for preparing 4,5-dihydro-4-oxofuran-2-carboxylic acid derivatives
-
, (2008/06/13)
Derivatives of 4,5-dihydro-4-oxofuran-2-carboxylic acid characterized by having two substituents at position 5 and in addition being optionally further substituted at position 3 with a lower alkyl group, as well as esters therefor are disclosed. The foreg
