77124-18-6Relevant articles and documents
Highly enantioselective construction of the α-chiral center of amides via iridium-catalyzed hydrogenation of α,β-unsaturated amides
Lu, Wei-Jing,Hou, Xue-Long
supporting information; experimental part, p. 1224 - 1228 (2009/12/06)
The chiral center at the a-position of amides is installed in excellent enantioselectivity via the iridium-catalyzed asymmetric hydrogenation of αβ-unsaturated amides under mild conditions. Even aliphatic amides are suitable substrates. The presence of a
Phosphite-Mediated in Situ Carboxyvinylation: A New General Acrylic Acid Synthesis
Brittelli, David R.
, p. 2514 - 2520 (2007/10/02)
Sequential treatment of a 2-halo carboxylic acid with a dialkyl phosphite and an aldehyde or ketone in the presence of 3 equiv of sodium hydride in glyme constitutes a new general acrylic acid synthesis superior to conventional methods.An alkoxide-in-alcohol variant may be used with bromo- or chloroacetic acid and aryl aldehydes to produce cinnamic acids conveniently.The scope and other features of the synthesis are discussed.
