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77130-75-7

N-ACETYL-N-HYDROXY-2-PHENYLACETAMIDE, commonly referred to as NAPA, is a synthetic organic compound that is a metabolite of acetaminophen, a widely used analgesic and antipyretic. Derived from acetaminophen, NAPA has been identified as a potentially toxic substance, with some studies indicating its harmful effects on the liver and kidneys in animals. It is also recognized as an impurity in certain pharmaceutical formulations of acetaminophen. Due to its potential toxicity, NAPA is a chemical compound that necessitates careful monitoring and consideration in healthcare and pharmaceutical applications.

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  • 77130-75-7 Structure

  • Basic information

    1. Product Name: N-ACETYL-N-HYDROXY-2-PHENYLACETAMIDE
    2. Synonyms: N-HYDROXY-N-PHENYLACETYL-ACETAMIDE;N-ACETYL-N-HYDROXY-2-PHENYLACETAMIDE
    3. CAS NO:77130-75-7
    4. Molecular Formula: C10H11NO3
    5. Molecular Weight: 193.2
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 77130-75-7.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: N-ACETYL-N-HYDROXY-2-PHENYLACETAMIDE(CAS DataBase Reference)
    10. NIST Chemistry Reference: N-ACETYL-N-HYDROXY-2-PHENYLACETAMIDE(77130-75-7)
    11. EPA Substance Registry System: N-ACETYL-N-HYDROXY-2-PHENYLACETAMIDE(77130-75-7)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 77130-75-7(Hazardous Substances Data)

77130-75-7 Usage

Uses

Given the provided materials, there are no specific applications listed for N-ACETYL-N-HYDROXY-2-PHENYLACETAMIDE (NAPA). The primary focus of the information provided is on its potential toxicity and its role as a metabolite and impurity in acetaminophen formulations. Therefore, it is not typically used as an active ingredient or for specific applications in various industries due to its associated risks. Instead, efforts in pharmaceutical development and healthcare may focus on minimizing its presence in medications to reduce the risk of adverse effects.

Check Digit Verification of cas no

The CAS Registry Mumber 77130-75-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,7,1,3 and 0 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 77130-75:
(7*7)+(6*7)+(5*1)+(4*3)+(3*0)+(2*7)+(1*5)=127
127 % 10 = 7
So 77130-75-7 is a valid CAS Registry Number.

77130-75-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name N-ACETYL-N-HYDROXY-2-PHENYLACETAMIDE

1.2 Other means of identification

Product number -
Other names Benzeneacetamide,N-acetyl-N-hydroxy

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:77130-75-7 SDS

77130-75-7Relevant articles and documents

A NOVEL ELECTROPHILIC N-AMIDATION VIA ELECTRON DEFICIENT COMPLEXES : ACTION OF FERRIC CHLORIDE OF N-ACETYLOXYAMIDES

Cherest, Marc,Lusinchi, Xavier

, p. 715 - 718 (2007/10/02)

The action of FeCl3 on N-acetyloxyamides leads to electron deficient species which can react intra or intermolecularly with an aromatic group to give oxindoles or analogues.

SUR LA TRANSFORMATION DU β-NITROSTYRENE SOUS L'ACTION DU CHLORURE D'ACETYLE EN PRESENCE D'UN CHLORURE METALLIQUE

Guillaumel, Jean,Demerseman, Pierre,Clavel, Jean-Marc,Royer, Rene,Platzer, Nicole,et al.

, p. 2459 - 2465 (2007/10/02)

While β-nitrostyrene yields only hydroxymic or hydroxamic acid derivatives by treatment with acetyl chloride in the presence of zinc, tin, titanium or aluminium chloride, it also gives 3-chloro-2-indolinone and a 5-acetyl derivative of the latter, when th

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