77143-69-2Relevant academic research and scientific papers
Benzofuran Derivatives: Part III - Rearrangement During Cyclization of Ethyl &α-(4-Methoxycarbonylalkylphenoxy)arylacetates and Formation of 3-Aryl-2(3H)-benzofuranone-5-alkanoic Acid Esters
Shridhar, D. R.,Sastry, C. V. Reddy,Mehrotra, A. K.,Bansal, O. P.
, p. 891 - 893 (2007/10/02)
Treatment of ethyl α-(4-methoxycarbonylalkylphenoxy)arylacetates (III) with conc.H2SO4 or PPA leads to 3-aryl-2(3H)-benzofuranone-5-alkanoic acid esters (V), via rearrangement and cyclization.Acid hydrolysis of V furnishes 3-aryl-2(3H)-benzofuranone-5-alkanoic acids (VI).These compounds show a moderate antiinflammatory activity.
