771477-48-6

Basic information

• Product Name: 3-(2-phenylethynyl)-4H-chromen-4-one
• Synonyms: 3-(2-phenylethynyl)-4H-chromen-4-one
• CAS NO: 771477-48-6
• Molecular Weight: 246.265
• Mol File: 771477-48-6.mol

Chemical Properties

• CAS DataBase Reference: 3-(2-phenylethynyl)-4H-chromen-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-phenylethynyl)-4H-chromen-4-one(771477-48-6)
• EPA Substance Registry System: 3-(2-phenylethynyl)-4H-chromen-4-one(771477-48-6)

Safety Data

• Hazardous Substances Data: 771477-48-6(Hazardous Substances Data)

Upstream product

• 49619-82-1 3-bromo-4H-chromen-4-one 
• 536-74-3 phenylacetylene 
• 1776-08-5 (E)-3-(dimethylamino)-1-(2-hydroxyphenyl)prop-2-en-1-one 
• 591-50-4 iodobenzene 
• 67271-48-1 3-ethynylchromone 
• 118-93-4 o-hydroxyacetophenone 
• 122775-34-2 3-iodo-chromen-4-one 

Downstream Products

• 948836-57-5 2-(2-hydroxyphenyl)-5-phenylfuran-3-carbaldehyde 
• 1190871-14-7 methyl 3-hydroxy-9-oxo-4-phenyl-9H-xanthene-2-carboxylate 
• 1215082-60-2 C₂₄H₁₈O₃ 
• 1100089-82-4 4-methoxy-2,3-diphenyl-4H-furo[3,2-c]chromene 
• 1380762-22-0 4-phenyl-3-(4-(trifluoromethyl)phenyl)-10H-chromeno[3,2-c]pyridin-10-one 
• 1380762-26-4 4-phenyl-10H-chromeno[3,2-c]pyridin-10-one 
• 1380762-17-3 4-phenyl-3-(2-(trifluoromethyl)phenyl)-10H-chromeno[3,2-c]pyridin-10-one 
• 1380762-24-2 ethyl 4-(10-oxo-4-phenyl-10H-chromeno[3,2-c]pyridin-3-yl)benzoate 
• 1380762-19-5 4-phenyl-3-(3-(trifluoromethyl)phenyl)-10H-chromeno[3,2-c]pyridin-10-one 
• 1380762-25-3 3-(2-amino-3,5-dibromophenyl)-4-phenyl-10H-chromeno[3,2-c]pyridin-10-one 
• 1380762-16-2 3-(4-chlorophenyl)-4-phenyl-10H-chromeno[3,2-c]pyridin-10-one 
• 1380762-13-9 3-(2-chlorophenyl)-4-phenyl-10H-chromeno[3,2-c]pyridin-10-one 
• 1380762-01-5 3,4-diphenyl-10H-chromeno[3,2-c]pyridin-10-one 
• 1380762-10-6 3-(4-hydroxyphenyl)-4-phenyl-10H-chromeno[3,2-c]pyridin-10-one 

Relevant articles and documents

Synthesis of 3,4,5-Trisubstituted Isoxazoles via the ANRORC Rearrangement

A facile and versatile procedure for the synthesis of new functionalized derivatives of 3-benzyl-5-(2-hydroxyphenyl) isoxazole-4-carbaldehyde oxime has been described. The key step in the synthesis involves the ANRORC reaction of in-situ generated 3-(phen

A facile strategy for accessing 3-alkynylchromones through gold-catalyzed alkynylation/cyclization of o-hydroxyarylenaminones

A strategy based on tandem alkynylation of o-hydroxyarylenaminones followed by intramolecular cyclization has been developed to generate a diverse array of 3-alkynyl chromones. The functionality embedded in these key intermediates enables their facile elaboration into more diverse structures by a variety of functionalizations and ring-forming processes.

C-alkynylation of chromones by sonogashira reaction

Sonogashira reaction of bromochromones and-flavones with a bromine atom on their benzene or heterocyclic ring with various terminal alkynes gave the desired products with nearly the same efficiency as the previously used iodine derivatives. The coupling reactions were performed in the presence of [tetrakis(triphenylphosphine)palladium(0)], copper(i) co-catalyst, and triethylamine, resulting in the formation of numerous hitherto unknown alkynylated oxygen heterocycles, and provide further proof for the applicability of this reaction for these O-heterocycles. Chromones with ethynyl functionality were prepared by removal of the trimethylsilyl protecting group and used as terminal alkynes in a second cross-coupling reaction.

Three-component one-pot approach to synthesize benzopyrano[4,3-d ]pyrimidines

A novel benzopyrano[4,3-d]pyrimidine scaffold was generated via a three-component one-pot reaction from iodochromone, alkyne, and an amidine through a Sonogashira coupling, condensation, and cycloaddition. This combinatorial synthetic approach provides an efficient, easy construction of a diversified heterocyclic compounds library.

AuCl3-catalyzed synthesis of highly substituted furans from 2-(1-alkynyl)-2-alken-1-ones

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