77148-75-5Relevant academic research and scientific papers
Anti-ulcer and gastric antisecretory activity of a series of thioethers and related sulphoxides
Beattie,Crossley,Dickinson,Dover
, p. 277 - 285 (2007/10/02)
A series of thioethers containing a pyridinium moiety were prepared and tested for gastric antisecretory and anti-ulcer activity. Following initial screening two compounds 2-(3-chlorobenzylthio)-1-methylpyridinium chloride and 2-(2-fluorobenzylthio)-1-methylpyridinium chloride were investigated further. By modification of substituent groups some separation of anti-ulcer and antisecretory activity was achieved. Subsequently it was found that the pyridinium moiety could be replaced and a number of related thioethers and sulphoxides were synthesised and were also found to be active. A wide range of structural variations were found to be possible with retention of activity.
Treatment of ulcers and hypertension
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, (2008/06/13)
The invention concerns the treatment of ulcers and hypersecretion in a mammal using compounds of the formula I where Ar is phenyl, which may be substituted or cycloalkyl of 5 to 7 carbon atoms, A is saturated or unsaturated lower alkylene which may be
