2044-27-1

Basic information

• Product Name: 1-methylpyridine-2-thione
• Synonyms: 1-methylpyridine-2-thione;1-Methyl-1,2-dihydropyridine-2-thione;1-Methyl-2(1H)-pyridinethione
• CAS NO: 2044-27-1
• Molecular Formula: C₆H₇NS
• Molecular Weight: 125.19
• Mol File: 2044-27-1.mol

Chemical Properties

• Boiling Point: 187.6 °C at 760 mmHg
• Flash Point: 67.2 °C
• Appearance: /
• Density: 1.16 g/cm³
• Vapor Pressure: 0.626mmHg at 25°C
• Refractive Index: 1.636
• CAS DataBase Reference: 1-methylpyridine-2-thione(CAS DataBase Reference)
• NIST Chemistry Reference: 1-methylpyridine-2-thione(2044-27-1)
• EPA Substance Registry System: 1-methylpyridine-2-thione(2044-27-1)

Safety Data

• Hazardous Substances Data: 2044-27-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1-Methylpyridine-2-thione is used as a building block for the synthesis of various pharmaceuticals due to its versatile chemical properties.
Used in Agricultural Industry:
1-Methylpyridine-2-thione is used as a building block for the synthesis of various agrochemicals, contributing to the development of effective crop protection agents.
Used in Corrosion Inhibition:
1-Methylpyridine-2-thione is studied for its potential use as a corrosion inhibitor, offering protection against metal degradation in various industrial applications.
Used in Synthesis of Metal Complexes:
1-Methylpyridine-2-thione serves as a precursor for the synthesis of metal complexes, which have applications in various fields such as catalysis and materials science.
Used in Biological Activities Research:
1-Methylpyridine-2-thione has been investigated for its potential biological activities, including antimicrobial, antifungal, and antioxidant properties, indicating its potential use in healthcare and life sciences.
However, it is important to handle 1-methylpyridine-2-thione with caution due to its toxic nature if ingested, inhaled, or in contact with skin.

InChI:InChI=1/C6H7NS/c1-7-5-3-2-4-6(7)8/h2-5H,1H3

Upstream product

• 534-18-9 sodium trithiocarbonate 
• 75-64-9 tert-butylamine 
• 100-46-9 benzylamine 
• 95-53-4 o-toluidine 
• 87-62-7 2,6-dimethylaniline 
• 95-54-5 1,2-diamino-benzene 
• 62-53-3 aniline 
• 109-73-9 N-butylamine 
• 107-15-3 ethylenediamine 
• 75-31-0 isopropylamine 
• 63434-91-3 2-(methyldisulfanyl)pyridine 
• 108-98-5 thiophenol 
• 104-94-9 4-methoxy-aniline 
• 106-47-8 4-chloro-aniline 

Downstream Products

• 109-09-1 2-chloropyridine 
• 62058-65-5 2-benzylsulfanyl-1-methyl-pyridinium; bromide 
• 77148-76-6 1-methyl-2-phenacylmercapto-pyridinium; bromide 
• 41681-14-5 1-Methyl-2-(methylthio)pyridinium iodide 
• 4088-63-5 1-methyl-2(1H)-pyridinimine 
• 77148-44-8 C₁₂H₁₃N₂S⁽¹⁺⁾*ClH*Cl^(1-) 
• 77148-66-4 2-(4-Chlorobenzylthio)-1-methylpyridinium chloride 
• 77148-87-9 2-((2-chlorobenzyl)thio)-1-methylpyridinium chloride 
• 77148-67-5 2-(2,6-dichlorobenzylthio)-1-methylpyridinium chloride 
• 93427-47-5 N-(1,2-Dihydro-1-methyl-2-pyridyliden)-p-methoxybenzolsulfonamid 
• 77148-71-1 1-Methyl-2(4-methylbenzylthio)pyridinium bromide 
• 62058-66-6 1-Methyl-2-(2-phenylethylthio)-pyridinium bromide 
• 77148-77-7 1-Methyl-2-((E)-3-phenyl-allylsulfanyl)-pyridinium; bromide 
• 77148-74-4 2-(4-Bromobenzylthio)-1-methylpyridinium bromide 

Relevant articles and documents

A New Procedure for the Conversion of Thiols into Reactive Sulfenylating Agents

Thiols may be converted in high yield into unsymmetrical 2-pyridyl disulfides 3.Treatment of these with alkylating agents (e.g., alkyl fluorosulfonates or oxonium salts) affords the corresponding N-alkylpyridyl disulfides 4, which are potent sulfenylating agents (Scheme II) and react smoothly with a variety of sulfur nucleophiles (e.g., thiols, thiones, thioamides, dithiocarbamates, thiocyanate, etc.) to afford disulfides, with amines to afford sulfenamides, and with β-diketones to afford sulfides.This new method is particularly well-suited to the preparation of unsymmetrical disulfides and sulfenamides from complex and otherwise r eactive thiols.

A Convenient Preparation of Bis(phosphorothioyl) Sulfides

The reaction of piperidinium and potassium phosphorodithioates with 2-chloro-1-methyl-pyridinium salts afforded the corresponding bis(phosphorothioyl) sulfides in good yields.The similar reaction with potassium diphenylphosphorothioate gave exclusively bis(diphenylphosphorothioyl) oxide. - Keywords: Bis(phosphorothioyl) Sulfides, Piperidinium Phosphorodithioates, Bis(phosphorothioyl) Oxides

A CONVENIENT METHOD FOR THE PREPARATION OF N,N'-DISUBSTITUTED THIOUREAS USING 2-CHLOROPYRIDINIUM SALT, SODIUM TRITHIOCARBONATE AND AMINES

N,N'-Disubstituted thioureas were prepared in high yields by treating 2-chloropyridinium salt with sodium trithiocarbonate and subsequently adding amines.