77149-11-2

Basic information

• Product Name: Benzoic acid, 2-Mercapto-3-Methyl-
• Synonyms: Benzoic acid, 2-Mercapto-3-Methyl-;2-mercapto-3-methylbenzoic acid
• CAS NO: 77149-11-2
• Molecular Formula: C₈H₈O₂S
• Molecular Weight: 168.21292
• Mol File: 77149-11-2.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Benzoic acid, 2-Mercapto-3-Methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 2-Mercapto-3-Methyl-(77149-11-2)
• EPA Substance Registry System: Benzoic acid, 2-Mercapto-3-Methyl-(77149-11-2)

Safety Data

• Hazardous Substances Data: 77149-11-2(Hazardous Substances Data)

Upstream product

• 13363-59-2 2,2'-dithiobis<3-methylbenzoic acid> 
• 80447-63-8 2-<(ethoxythioxomethyl)thio>-3-methylbenzoic acid 
• 4389-45-1 3-methylantranilic acid 
• 140-89-6 potassium ethyl xanthogenate 
• 497-19-8 sodium carbonate 
• 139127-55-2 methyl 2-N,N-dimethylthiocarbamoyloxy-3-methylbenzoate 
• 23287-26-5 3-methylsalicylic acid methyl ester 

Downstream Products

• 83596-83-2 2-(acetylthio)-3-methylbenzoic acid 
• 13363-60-5 2,2'-dithiobis<3-methylbenzoyl chloride> 
• 13363-59-2 2,2'-dithiobis<3-methylbenzoic acid> 

Relevant articles and documents

HETEROCYCLIC DERIVATIVE HAVING INHIBITORY ACTIVITY ON TYPE-I 11 -HYDROXYSTEROID DEHYDROGENASE

Disclosed is a compound which is useful as an 11β-hydroxysteroid dehydrogenase type 1 inhibitor. A compound represented by the formula: its pharmaceutically acceptable salt, or a solvate thereof, wherein X is O or S, a broken line and a wavy line represent the presence or the absence of a bond, (i) when a broken line represents the presence of a bond, a wavy line represents the absence of a bond, R2 and R3 are each independently hydrogen, halogen, cyano, hydroxy, carboxy, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl or the like, (ii) when a broken line represents the absence of a bond, a wavy line represents the presence of a bond, R1 and R4 are each independently hydrogen, halogen or the like, R2 and R3 are each independently hydrogen, halogen, cyano, hydroxy, carboxy, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl or the like, and R5 and R6 are each independently hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl or the like.

Substituent effects on the reactivity of benzo-1,2-dithiolan-3-one 1-oxides and their possible application to the synthesis of DNA-targeting drugs

The efficiency of polysulfane product generation has been investigated for n-propyl thiol reactions with ortho- and para-substituted benzo-1,2-dithiolan-3- one 1-oxides in acetonitrile-water (7:3) mixtures. The reaction is facilitated by reducing the electron density at the para position or by placing substituents bearing lone pair electrons ortho to the dithiolanone-oxide (S1) reaction center. Through-space and through-bond effects both contribute to the conversion of polysulfane products.

Aroyl-aminoacids, amides and esters thereof

Compounds of the structure STR1 wherein: Q is oxygen, sulfur or imino.X and Y are hydrogen, halogen, hydroxy, alkoxy, trifluoromethyl, nitro, carboxy, cyano, sulfonamido, sulfhydryl, alkyl, alkenyl, alkynyl, alkanoyl, alkylmercapto, amino, alkylamino, dialkylamino, alkysulfinyl, and alkylsulfonyl and may be the same or different;R 1 is hydrogen, alkanoyl, substituted alkanoyl wherein the substituent is hydroxy, amino or cycloalkyl, aroyl, arylalkanoyl, or cycloalkylcarbonyl,n is an integer from 1 to 4 inclusive,R 2 and R 3 are hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkyl-alkyl, aryl, aralkyl, and substituted derivatives thereof wherein the substituents are hydroxy, amino, alkylamino, dialkylamino, alkoxy, halogen, hydroxy, mercapto, alkylmercapto and nitro, and may be the same or different;M is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, and hetero; andZ is hydroxy, amino, alkylamino, dialkylamino, or alkoxy,have angiotensin converting enzyme inhibitory activity.