771499-34-4Relevant academic research and scientific papers
Structure-guided design of pyrazolo[1,5-a]pyrimidines as inhibitors of human cyclin-dependent kinase 2
Williamson, Douglas S.,Parratt, Martin J.,Bower, Justin F.,Moore, Jonathan D.,Richardson, Christine M.,Dokurno, Pawel,Cansfield, Andrew D.,Francis, Geraint L.,Hebdon, Richard J.,Howes, Rob,Jackson, Philip S.,Lockie, Andrea M.,Murray, James B.,Nunns, Claire L.,Powles, Jenifer,Robertson, Alan,Surgenor, Allan E.,Torrance, Christopher J.
, p. 863 - 867 (2005)
The protein structure guided design of a series of pyrazolo[1,5-a] pyrimidines with high potency for human cyclin-dependent kinase 2 (CDK2) is described. Some examples were shown to inhibit the growth of human colon tumour cells, were equipotent for CDK1 and were selective against GSK-3β and other kinases.
PYRAZOLOPYRIMIDINE COMPOUNDS AND THEIR USE IN MEDICINE
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Page 32, (2010/02/08)
Compounds of formula (I) or salts, N-oxides, hydrates or solvates thereof are inhibitors of kinase activity, and useful for the treatment of, for example, cancer, psoriasis or restenosis: wherein ring A is an optionally substituted carbocyclic or heterocy
