771557-97-2Relevant academic research and scientific papers
Structure-based design of pyridopyrimidinediones as dipeptidyl peptidase IV inhibitors
Lam, Betty,Skene, Robert J.,Zhang, Zhiyuan,Stafford, Jeffery A.,Shi, Lihong,Gwaltney II, Stephen L.
, p. 6628 - 6631,4 (2012)
Dipeptidyl peptidase IV (DPP-4) inhibitors have been shown to enhance GLP-1 levels and thereby improve hyperglycemia in type II diabetes. From a small fragment hit, using structure-based design, we have discovered a new class of non-covalent, potent and s
